ADRA2B

(redirected from alpha-2B adrenergic receptor)

ADRA2B

A gene on chromosome 2p13-q13 that encodes alpha-2B-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which plays a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the CNS, smooth muscle contraction and thermoregulation. The alpha2B subtype associates with EIF-2B, a guanine nucleotide exchange protein that regulates translation.

ADRA2A agonists
Clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine.

ADRA2A antagonists
Yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin >
alprenolol > propanolol > pindolol.
References in periodicals archive ?
Identification of a three-amino acid deletion in the alpha-2B adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.
A functional polymorphism in the alpha-2B adrenergic receptor gene, a positional candidate gene on chromosome 2, is associated with hypertension in Swedes.