* The report provides a snapshot of the global therapeutic landscape for Complement C5 (C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4)
* The report reviews Complement C5 (C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Active PSA forms stable, 1:1 complexes with alpha-1-antichymotrypsin (PSA-ACT), protein C inhibitor (PSA-PCI), alpha-1-protease inhibitor (PSA-API), and alpha-2-macroglobulin
Pizzo and Gron, which allows us to incorporate a wide variety of subunit vaccine candidates into alpha-2-Macroglobulin
(SynerVax adjuvant) with minimal disturbance to the natural structure of these proteins or peptides.
Abbreviations ECM: Extracellular matrix COMP: Cartilage oligomeric matrix protein ADAMTS: A disintegrin and metalloproteinase with thrombospondin motifs MMP: Matrix metalloproteinase IVD: Intervertebral disc PTHrP/PTHLH: Parathyroid hormone-like hormone MARE: Maf recognition element BDE: Brachydactyly type E SNPs: Single nucleotide polymorphisms OA: Osteoarthritis RA: Rheumatoid arthritis CAIA: Collagen antibody-induced arthritis GEP: Granulin-epithelin precursor [[alpha].sub.2]M: Alpha-2-macroglobulin NP: Nucleus pulposus EVT: Extravillous cytotrophoblast GnRH: Gonadotropin-releasing hormone.
Howell et al., "Inhibition of ADAMTS7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin, " Osteoarthritis and Cartilage, vol.
An elevation of 42 % was exhibited by alpha-2-macroglobulin (190 kDa) in patients of valvular heart disease.
The behavior of antithrombin III, alpha-2-macroglobulin, and alpha-1-antitrypsin during ardiopulmonary bypass.
The eletrophoretically 'slow' and 'fast' forms of the alpha-2-macroglobulin molecule.
The interaction of alpha-2-macroglobulin with proteinases: characteristics and specificity of the reaction and a hypothesis concerning its molecular mechanism.
Interaction between serratia protease and human plasma alpha-2-macroglobulin. J Biochem 1981;89:1231-7.
Purification of human alpha-2-macroglobulin and alpha-1-proteinase inhibitor using zinc chelate chromatography.