SERPINF2

(redirected from alpha-2-antiplasmin)

SERPINF2

A gene on chromosome 17p13 that encodes alpha-2-antiplasmin, a serine protease inhibitor (serpin). SERPINF2 inhibits plasmin, which degrades fibrin and other proteins, and thus plays a cental role in regulating coagulation.

Molecular pathology
SERPINF2 mutations result in alpha-2-plasmin inhibitor deficiency, which is characterised by severe haemorrhagic diathesis.
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References in periodicals archive ?
Rijken, "Increased N-terminal cleavage of alpha-2-antiplasmin in patients with liver cirrhosis," Journal of Thrombosis and Haemostasis, vol.
Rijken, "Plasma levels of soluble fibroblast activation protein in arterial thrombosis; Determinants and cleavage of its substrate alpha-2-antiplasmin," International Journal of Cardiology, vol.

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