Plasminogen, AT3, protein C and S, alpha-2 antiplasmin and alpha-1 antitrypsin are also produced in the liver.
The production of plasminogen, alpha-2 antiplasmin, histidine-rich glycoprotein and FXIII is decreased in liver diseases.
Measurements included complete blood count (CBC); platelets; PT; activated partial thromboplastin time (APTT); fibrinogen (clottable, immunological); coagulation factors II, V, VII, VIII, IX, X, XI, XII; anti-thrombin (AT); alpha-2 antiplasmin (AP); Protein C (PC); mixing studies; lupus anticoagulant screening; plasminogen; thrombin-anti-thrombin; fibrin degradation products (FDP); d-dimer; and thrombin time.
We then performed PT; activated partial thromboplastin time (APTT); fibrinogen (clottable and immunological); d-dimer; reptilase time; thrombin times; coagulation factors II, V, VII, VIII, IX, X, XI, XII; anti-thrombin (AT); alpha-2 antiplasmin (AP); protein C (PC); mixing studies (using rabbit normal plasma); lupus anticoagulant screening and confirmatory testing (dilute Russell's viper venom [American Diagnostica, Greenwich CT], STACLOT LA, [Diagnostica-Stago, Inc., Parsippany NJ] ); and plasminogen using reagents from Diagnostica-Stago, Inc.
This may be related to the repeated blood draws and not the effect of the BRSV Anti-thrombin and alpha-2 antiplasmin levels were increased in test subjects receiving the BRSV(p<0.05).