SERPINA1

(redirected from alpha-1-antiproteinase)

SERPINA1

A gene on chromosome 14q32.1 that encodes a member of the serine protease inhibitor (serpin) family, whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin and plasminogen activator, the latter three of which it irreversibly inhibits. 

Molecular pathology
SERPINA1 mutations cause pulmonary emphysema and liver disease.
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All NT coronas were found to consist of 14 common proteins, including alpha-1-antiproteinase, alpha-2-HS-glycoprotein, alpha-S1-casein, apolipoprotein A-I, apolipoprotein A-II, keratin, type I cytoskeletal 10, keratin, type I cytoskeletal 15, keratin, type II cytoskeletal 1, keratin, type II cytoskeletal 5, keratin, type II cytoskeletal 6A, keratin, type II cytoskeletal 6C, keratin, type II cytoskeletal 75, serum albumin, and titin.
Protection against peroxynitrite-dependent tyrosine nitration and alpha-1-antiproteinase inactivation by ascorbic acid.

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