In alpha thalassemia
, alpha globin expression is deficient and there is a corresponding excess of beta globin chains.
KEY WORDS: Alpha thalassemia
, Beta thalassemia major, Co-inheritance, Genetic analysis, a3.
in blacks: genetic and clinical aspects and interactions with sickle hemoglobin gene.
Genetic studies are indicated to confirm borderline cases and to detect silent carriers of beta thalassemia, alpha thalassemia
, and rare and novel variants in routine practice.
A 49-year-old African-American male with a past medical history of the alpha thalassemia
trait who had a three-year history of marginal zone monocytoid B-cell non-Hodgkin lymphoma (NHL), which was diagnosed on a lymph node and bone marrow biopsies, had a longstanding splenomegaly with symptoms of fever, night sweats, fatigue, weight loss, mild abdominal pain, and early satiety.
major--new mutations, intrauterine management, and outcomes.
2, and -MED mutations as common alpha thalassemia
gene mutations in Iran.
SYMPTOMS: The most severe form of alpha thalassemia
major causes stillbirth (death of the unborn baby during birth or the late stages of pregnancy).
The patented test detects Alpha Thalassemia
mutations and their use as predictors of blood-related disorders.
In the worst cases of Thalassemia, where a patient is diagnosed with Alpha Thalassemia
Major (all four of the alpha globin genes are abnormal or missing), some patients may not survive past childhood.
Positive identification of the presence of Constant Spring is critical in that it can be a severe form of alpha thalassemia
and a predictor of potential hemoglobin H disease in the future.
Beta Thalassemia is more common in Pakistan as compared to Alpha Thalassemia