This patent broadly claims composition of matter for antibodies that cross-neutralize Staphylococcus aureus
alpha hemolysin and up to four additional S.
Inhibitory effect of SNPs on alpha hemolysin, a well-known virulence factor of S.
Alpha hemolysin expression was also effectively inhibited by SNPs treatment.
Conclusion: In general, results revealed formation of spherical silver nanoparticles with inhibitory effects on bacterial growth and antagonist activity on the expression of alpha hemolysin. Moreover, increase in pH to basic condition resulted in aggregation of nanoparticles and formation of rod-like nanostructures.
Real time PCR (RT-PCR) assay was conducted to assess expression of alpha hemolysin (hla) under SNPs treatment.
As can be seen, a dose-dependent decrease in expression of alpha hemolysin under treatment with various concentrations of SNPs was recorded.
aureus, their influence on expression of alpha hemolysin as a major virulence factor of the pathogen was also evaluated.
coli significantly induced colonic tumorigenesis in female mice by activating the oncogenic protein GLUT1 expression and repressing the tumor suppressor BIM expression by elevating levels of HIF-1[alpha], in a manner dependent on the hly-encoded
alpha hemolysin [14].
Wadstrom, "Virulence of Staphylococcus aureus in a mouse mastitis model: studies of
alpha hemolysin, coagulase, and protein A as possible virulence determinants with protoplast fusion and gene cloning," Infection and Immunity, vol.
Alpha hemolysin (?HL), a bacterium that causes lysis of red blood cells, seemed a particularly promising candidate, given the nanopore diameter required for sequencing DNA.
Other researchers noticed in the early 1990s that an enzyme called
alpha hemolysin pokes nanosize holes into the cell membranes of organisms that some bacteria have infected.
