alpha blocker


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alpha blocker

An agent that blocks activity at the alpha-adrenergic receptors, which are used as second-line antihypertensives. Alpha blockers provide symptomatic relief for benign prostate hypertrophy.

Examples
Doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin).
 
Side effects
Dizziness, headache, weakness, nasal congestion, fluid retention, drowsiness.
References in periodicals archive ?
Table 1 : Change in IPSS Score--Before and after administration of PDE5 inhibitor: Tadalafil Dose 5mg once daily Group Incomplete Frequency Intermittency Emptying Patients on N 60 60 60 Alpha Blocker Mean 4.
1 Recently many agents such as calcium channel blockers, corticosteroids, non-steroidal anti-inflammatory drugs and alpha blockers have been used to facilitate stone passage along the ureter.
Patients in whom alpha blockers were administered due to the growth of postoperative adenoma and who had been operated on due to urethral stricture, bladder neck contracture or a growing adenoma were also noted and recorded.
Hytrin is the only alpha blocker now approved for BPH treatment by the Food and Drug Administration.
In the ALLHAT study, diuretic drugs were compared to angiotensin-converting enzyme (ACE) inhibitors that widen blood vessels and decrease resistance, calcium channel blockers that relax vessels by slowing the flow of calcium into the heart and alpha blockers, which also relax blood vessels.
Medical expulsive therapy (MET) administered with calcium channel blockers (nifedipine) or alpha blockers increase the chance of spontaneous passage in over 80% of cases for ureteral stones.
For men with larger prostates, higher PSA levels and obstructive symptoms, a combination of an alpha blocker to provide fast relief and a 5-ARI may be prescribed.
6) Initial studies for the assessment of finasteride in combination with terazosin, doxazosin or alfuzosin were of short duration (6 months to 1 year) and failed to establish a benefit for combination therapy over placebo or alpha blocker monotherapy in terms of symptom improvement.
There is evidence that discontinuation of an alpha blocker after a period of combination therapy may provide durable symptom relief.