alpha blocker


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alpha blocker

An agent that blocks activity at the alpha-adrenergic receptors, which are used as second-line antihypertensives. Alpha blockers provide symptomatic relief for benign prostate hypertrophy.

Examples
Doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin).
 
Side effects
Dizziness, headache, weakness, nasal congestion, fluid retention, drowsiness.
References in periodicals archive ?
The role of alpha blockers as an adjunctive to ESWL for renal stones has emerged and is generally accepted for the last few years.
Patients in whom alpha blockers were administered due to the growth of postoperative adenoma and who had been operated on due to urethral stricture, bladder neck contracture or a growing adenoma were also noted and recorded.
know if alpha blocker drugs, finasteride, or balloon dilation lower the risk of future BPH problems.
The total IPSS score and obstructive and irritative IPSS sub scores were significantly improved after tadalafil therapy in combination with alpha blocker compared with alpha blocker alone.
In the ALLHAT study, diuretic drugs were compared to angiotensin-converting enzyme (ACE) inhibitors that widen blood vessels and decrease resistance, calcium channel blockers that relax vessels by slowing the flow of calcium into the heart and alpha blockers, which also relax blood vessels.
Nonselective alpha blockers carry a greater risk of a sudden drop in blood pressure (hypotension) and dizziness upon standing.
(38) The alpha blockers work by inhibiting [[alpha].sub.1] mediated sympathetic stimulation and thereby promote relaxation of bladder neck and prostatic smooth muscle.
There is evidence that discontinuation of an alpha blocker after a period of combination therapy may provide durable symptom relief.[sup.6,7] However, these studies lack both long-term data and rates of progression to surgical intervention.
A review of 53 cases of ruptured pheochromocytoma revealed that 17 (32%) of the patients died, and that no mortality occurred among the 12 patients who received an alpha blocker (for high blood pressure) and fluid infusion therapy before surgery.
Alpha blocker therapy can be withdrawn in the majority of men following initial combination therapy with the dual 5-alpha reductase inhibitor dutasteride.
Now there are three classes of medications: alpha blockers (Tamsulosin and others), 5-alpha reductase inhibitors (Finasteride and others) and the phosphodiesterase-5 Inhibitor Tadalafil.