alpha 1 -antitrypsin


a member of the serpin group, a plasma protein (α1-globulin), produced primarily in the liver. It inhibits the activity of elastase, cathepsin G, trypsin, and other proteolytic enzymes. Congenital deficiency of this protein is associated with development of emphysema in young adulthood. Written also α1-antitrypsin. Called also alpha1-proteinase inhibitor.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
References in periodicals archive ?
Alpha 1 -Antitrypsin deficiency is a genetic defect that can lead to the development of severe panacinar emphysema.
Some proteins (alpha 1 -antitrypsin, alpha 1-acid glycoprotein, haptoglobin, ceruloplasmin, C4, C3 and C-reactive protein) will increase in response to an acute-phase reaction and are known as positive acute- phase proteins.

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