alosetron


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alosetron

(a-low-se-tron) ,

Lotronex

(trade name)

Classification

Therapeutic: anti irritable bowel syndrome agents
Pharmacologic: five ht3 antagonists
Pregnancy Category: B

Indications

Treatment of severe diarrhea-predominant irritable bowel syndrome (IBS) in women who have chronic symptoms (≥6 mo), no other GI pathology, and have had no response to conventional therapy.

Action

5-HT3 receptors are non-selective cation channels responsible for regulation of visceral pain, colonic transit, and GI secretions. Alosetron inhibits the activation of these channels.

Therapeutic effects

Increased colonic transit time without affecting orocecal transit time resulting in decreased pain/discomfort and diarrhea associated with IBS.

Pharmacokinetics

Absorption: 50–60% absorbed following oral administration.
Distribution: 65–95 L.
Protein Binding: 82% bound to plasma proteins.
Metabolism and Excretion: Extensively metabolized by the liver; 13% excreted unchanged in urine.
Half-life: 1.5 hr.

Time/action profile (pain/discomfort, diarrhea)

ROUTEONSETPEAKDURATION
POwithin 1–2 wkup to 6 wk1 wk†
†Following discontinuation

Contraindications/Precautions

Contraindicated in: Hypersensitivity; Constipation; History of chronic/severe constipation or complications due to constipation; History of GI obstruction, stricture, toxic megacolon, perforation, and/or adhesions; History of ischemic colitis, ↓ intestinal circulation, thrombophlebitis, or coagulation defects; History of Crohn’s disease/ulcerative colitis/diverticulitis; Severe hepatic impairment; Concurrent use of fluvoxamine; Patients unable to understand or comply with Patient Acknowledgement Form.
Use Cautiously in: Men – safety not established; Mild-moderate hepatic impairment; Patients who are elderly, debilitated, or taking medications that ↓ GI motility; Obstetric / Lactation / Pediatric: Safety not established.

Adverse Reactions/Side Effects

Gastrointestinal

  • acute ischemic colitis (life-threatening)
  • toxic megacolon (life-threatening)
  • constipation (most frequent)
  • abdominal discomfort
  • abdominal distention
  • flatulence
  • nausea
  • GI viral infections
  • hemorrhoids
  • regurgitation or reflux

Interactions

Drug-Drug interaction

Fluvoxamine can ↑ levels; concurrent use contraindicated).Amiodarone, cimetidine, ciprofloxacin, clarithromycin, itraconazole, ketoconazole, ofloxacin, protease inhibitors, telithromycin, and voriconazole may ↑ levels; use concomitantly with caution.

Route/Dosage

Oral (Adults) Women—0.5 mg twice daily.

Availability

Tablets: 0.5 mg, 1 mg

Nursing implications

Nursing assessment

  • Monitor patient for signs of constipation or ischemic colitis (new or worsening abdominal pain, bloody diarrhea, blood in stool) throughout therapy. Patients should not start taking alosetron if they are constipated.
  • Discontinue therapy immediately if patient develops constipation or signs/symptoms of ischemic colitis.

Potential Nursing Diagnoses

Diarrhea (Indications)
Risk for constipation (Side Effects)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)

Implementation

  • Do not confuse Lotronex with Protonix.
  • Alosetron should only be prescribed by physicians enrolled in GlaxoSmithKline’s Prescribing Program for Alosetron.
  • Oral: Administer 0.5 mg twice daily for 4 wk. If constipation occurs after initiation of therapy, discontinue until constipation resolves, then restart at 0.5 mg once daily (if constipation recurs at this dose, discontinue therapy). If IBS symptoms are not controlled after 4 wk, no constipation has occurred and patient tolerates either 0.5 mg once or twice daily, dose may be increased to 1 mg twice daily. If symptoms are not controlled after 4 wk of 1 mg twice, discontinue alosetron.
  • Can be administered with or without food; however, administration with food may decrease absorption by 25%.

Patient/Family Teaching

  • Instruct patient to take alosetron exactly as directed. If a dose is missed, skip the dose and return to regular schedule; do not double doses. Counsel patients about the risks and benefits of alosetron and the impact of IBS symptoms on their life. Patients should read the Medication Guide before starting alosetron and each time they refill their prescription. The Patient-Physician Agreement should be signed, with the original in the patient’s chart and a copy to the patient, prior to initiating therapy.
  • Caution patient to stop taking alosetron and report constipation or signs of ischemic colitis to health care professional immediately. Immediately contact health care professional again if constipation does not resolve after discontinuation of alosetron. Alosetron should be resumed only after constipation has resolved and on the advice of their health care professional. Treatment with alosetron should not be resumed in patients who develop ischemic colitis.

Evaluation/Desired Outcomes

  • Increased colonic transit time without affecting orocecal transit time resulting in decreased pain, discomfort, and diarrhea associated with IBS.
References in periodicals archive ?
Eleven pharmaceutical agents or classes of drugs are used to treat IBS: linaclotide (Linzess), lubipro-stone (Amitiza), eluxadoline (Viberzi), polyethylene glycol laxatives (Miralax, Glycolax), rifaximin (Xifaxan), alosetron (Lotronex), loperamide (Imodium), tricyclic antidepressants (Elavil), selective serotonin reuptake inhibitors (Prozac, Zoloft) and antispasmodics (Atropine, Bentyl), and plecanatide (Trulance), approved in January 2017.
Previously at GlaxoSmithKline, he led clinical programs for the reintroduction of alosetron to the US market, the registration program for alvimopan, and medical affairs programs for assets within Womens Health, Urology, Acute Care, Gastrointestinal and Ophthalmologic business units.
FIGURE 3 harmacologic therapies for irritable bowel syndrome by symptom (13,14) Abdominal pain/-discomfort ** Antidepressants * (TCAs/SSRIs) ** Alosetron (5-THE antagonist) ** Dicyclomine ** Hyoscyamine * Constipation ** Fiber * ** MOM/PEG solution * ** Linaclotide (guanylate Cyclase-C agonist Bloating ** Rifaximin ** Probiotics * Diarrhea ** Loperamide * ** Diphenoxylate-astropine * ** Cholestyramine * ** Alosetron ** Rifaximin ** Eluxadoline * Not currently approved by the US Food and Drug Administration for the treatment of irritable bowel syndrome.
Late last month Amneal Pharmaceuticals LLC began shipping alosetron hydrochloride tablets, an AB-rated generic equivalent to Lotronex, in 0.
There are isolated reports of ischemic colitis associated with other drugs, like NSAIDs: alosetron (Lotronex, GlaxoSmithKline, Philadelphia, Pennsylvania), used for the management of severe diarrhea in irritable bowel syndrome in women only; pseudoephedrine; interferon; dopamine; and methysergide.
Alosetron es un farmaco antagonista 5-HT3 no comercializado en Espana que enlentece el transito colico y aumenta el umbral de percepcion durante la distension del colon.
Additional studies highlight the importance of serotonin reuptake transporter in IBS as polymorphisms in this gene resulted in a differential response to alosetron, a 5-HT3 receptor antagonist that is used to treat diarrhea-predominant IBS.
Alosetron (Lotronex) is approved for use in female patients who have severe diarrhea and abdominal pain as symptoms of IBS.
For diarrhoea forms of the condition, they evaluated tricyclic antidepressants; alosetron, a drug that slows movement of stool in the gut; and rifaximin, an antibiotic that stays in the gut and is used to treat traveller's diarrhoea and hepatic encephalopathy.
Numerous other agents are being made available or are in the process of being investigated, including lubiprostone (Amitiza), GnRH (gonadotropin-releasing hormone) analogues, and alosetron (Lotronex).
Effect of alosetron on responses to colonic distention in patients with irritable bowel syndrome.
3]-receptor antagonist alosetron benefits women with IBS-D, improving global symptoms and stool form.