allylamine


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al·lyl·a·mine

(al'il-ā-mēn'),
Member of a class of antifungal agents that works by inhibiting squalene epoxidase, an enzyme involved in the synthesis of ergosterol, a component of fungal cell walls.

allylamine

a group of fungicidal drugs which disrupt fungal cell wall formation, by inhibiting squalene epioxase activity (see terbinafine)
References in periodicals archive ?
12-14) It is a member of a new class of antifungal agents, the allylamines, which have a different mechanism of action (squalene epoxidase inhibitor) than the azoles have.
If you have a dry scaly process--with or without the collarettes--you're probably better with an allylamine, particularly if you use a keratolytic with it, something that has urea or a lactic acid," she said.
7% of the patients who were assigned to the topical allylamine, compared with 7.
Although the allylamine terbinafine is not used for treatment of patients with invasive aspergillosis, the drug is highly active against both E.
Posaconazole, a new broad-spectrum triazole, and terbinafine, an allylamine antifungal, have in vitro activity against these fungi.
Pat Mastin, chief of the NIEHS Cellular, Organ, and Systems Pathobiology Branch, points out that several occupational exposures also have been associated with CVD, including exposures to vinyl chloride (used to produce polyvinyl chloride and industrial solvents), carbon monoxide (a common exhaust gas), and allylamine (used in ion exchange resins, pharmaceuticals, and water-soluble polymers).
A new formulation of naftifine hydrochloride 2% (Naftin), a potent prescription topical allylamine antifungal available as a cream or a gel, has shown equivalent efficacy with just 2 weeks of treatment.
1), a synthetic allylamine antifungal agent, was used as the combination partner, since it is the preferred antifungal drug to treat mycoses produced by dermatophytes (Gokhale and Kulkarni 2000).
Abstract Terbinafine is an oral antimycotic agent that belongs to the allylamine class.
Terbinafine hydrochloride is a relatively new allylamine with a broad range of in vitro antifungal activity.
This article is continuation of that work and reports UV surface grafting of WGRT powder with allylamine.
Two classes of systemic agents commonly are used for the treatment of onychomycosis: azole antifungal agents--specifically, the triazoles fluconazole and itraconazole--and an agent from the allylamine class, terbinafine.