alloxan diabetes

al·lox·an di·a·be·tes

experimental diabetes mellitus produced in animals by the administration of alloxan, which damages the insulin-producing islet cells of the pancreas.

alloxan diabetes

An experimental model for type-1 diabetes induced by administration of alloxan, a toxic glucose analogue, which in the presence of intracellular thiols generates reactive oxygen species that selectively destroy pancreatic beta cells.
Mentioned in ?
References in periodicals archive ?
Effects of Vincarosea extracts in treatment of alloxan diabetes in albino rats.
Altura, "Vascular responsiveness and serum biochemical parameters in alloxan diabetes mellitus," The American Journal of Physiology, vol.
Effect of alloxan diabetes, starvation and refeeding on glycolytic kinase activities in rat epididymal adipose tissue.
The Pathological Features of Alloxan Diabetes in Beagle Dogs.
They were carried out on 36 rats weighed 170-178 gm under the terms of alloxan diabetes.
Effects of sodium--orthovanadate and Trigonella foenumgraecum seeds on hepatic and renal lipogenic enzymes and lipid profile during alloxan diabetes.
Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats.
Alloxan (meso-xylylurea) acts by selectively destroying the beta cell without affecting alpha cells of islets of langerhan's, thus resulting in hyper glycemia and ketoacedosis, moreover alloxan diabetes of varying degree of severity is accompanied by increased cholesterol and triglyceride levels.
On the other hand, oxidative phosphorylation functions; the activity of NADH dehydrogenase and succinate dehydrogenase in respiratory chain of liver mitochondria were normalized in rats with alloxan diabetes after oral administration of ecdysterone (Tashmukhamedova et al.