alloxan diabetes

al·lox·an di·a·be·tes

experimental diabetes mellitus produced in animals by the administration of alloxan, which damages the insulin-producing islet cells of the pancreas.

alloxan diabetes

An experimental model for type-1 diabetes induced by administration of alloxan, a toxic glucose analogue, which in the presence of intracellular thiols generates reactive oxygen species that selectively destroy pancreatic beta cells.
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References in periodicals archive ?
Changes in plasma glucagon, pancreatic polypeptide and insulin during development of alloxan diabetes mellitus in dog.
Nevertheless, under conditions of alloxan diabetes, a reduction in the eosinophil and neutrophil numbers in BAL was noted after OVA, although mononuclear cells were not affected (Figure 2(a)).
In diabetic rats, alloxan diabetes was induced by intraperitoneally injecting 1 ml of 5% alloxan at the beginning of the study Group Glycaemic Treatment status A Nondiabetic 1 ml distilled water (intraperitoneally) per day for 10 days B Diabetic 1 ml of a 5% solution of alloxan monohydrate at a dose of 125 mg/kg C Diabetic Alloxan monohydrate+glibenclamide (10 mg/kg).
Suryawanshi, "Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats," Indian Journal of Experimental Biology, vol.
Baquer, "Effects of sodium-orthovanadate and Trigonella foenum-graecum seeds on hepatic and renal lipogenic enzymes and lipid profile during alloxan diabetes," Journal of Biosciences, vol.
Effects of Vincarosea extracts in treatment of alloxan diabetes in albino rats.
Altura, "Vascular responsiveness and serum biochemical parameters in alloxan diabetes mellitus," The American Journal of Physiology, vol.
Alloxan diabetes induced biochemical changes in the blood and morphological and ultrastructural lesions in rat liver, ranging from steatosis to steatohepatitis and liver fibrosis, which closely resemble changes in the human liver.
Effect of alloxan diabetes, starvation and refeeding on glycolytic kinase activities in rat epididymal adipose tissue.
The Pathological Features of Alloxan Diabetes in Beagle Dogs.
They were carried out on 36 rats weighed 170-178 gm under the terms of alloxan diabetes. The animals were delivered with glicoinuvit perorally at a dose of 50 and 100 mg/kg, and lipoic acid-per 20 mg/kg.