Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to alloxan: streptozotocin
An oxidation product of uric acid, 2,4,5,6-pyrimidinetetrone; administration to experimental animals causes hypoglycemia resulting from insulin liberation, followed by hyperglycemia resulting from destruction of the islets of Langerhans (alloxan diabetes).
alloxan/al·lox·an/ (ah-lok´san) an oxidized product of uric acid that tends to destroy the islet cells of the pancreas, thus producing diabetes (alloxan diabetes).
an oxidation product of uric acid that is found in the human intestine in diarrhea. Alloxan has been used to produce diabetes in experimental animals by destroying the insulin-secreting islet cells of the pancreas.
alloxanAn oxygenated pyrimidine derivative, which is a toxic glucose analogue that induces experimental diabetes by selectively destroying pancreatic beta cells by superoxide production.
An oxidation product of uric acid.
n a substance, mesoxalyl urea, capable of producing experimental diabetes by destroying the islet cells of the pancreas.
an oxidized product of uric acid which destroys β cells of the islets of Langerhans in the pancreas. It has been used in experimental studies of diabetes mellitus and in the treatment of insulinomas in dogs.