alloxan


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Related to alloxan: streptozotocin

al·lox·an

(ă-loks'-an),
An oxidation product of uric acid, 2,4,5,6-pyrimidinetetrone; administration to experimental animals causes hypoglycemia resulting from insulin liberation, followed by hyperglycemia resulting from destruction of the islets of Langerhans (alloxan diabetes).

alloxan

An oxygenated pyrimidine derivative, which is a toxic glucose analogue that induces experimental diabetes by selectively destroying pancreatic beta cells by superoxide production.

al·lox·an

(AX) (ă-loks'an)
An oxidation product of uric acid.
References in periodicals archive ?
It aims to determine the effect of alloxan as an inducer in increasing blood sugar levels in animals used.
Pancreas samples from mice in the glibenclamide group also showed pyknotic cells, in addition to similar damage to the islets caused by alloxan and regeneration of the central islet region (Figure 2E).
Effect of Ficus relegiosa on blood glucose and total lipid levels of normal and alloxan diabetic rabbits.
Diabetes mellitus was induced by intravenous injection of alloxan monohydrate (60 mg/kg; Sigma Chemical Co., St.
Alloxan monohydrate, ovalbumin, methacholine, streptomycin, penicillin, EDTA, paraformaldehyde, and HBSS were purchased from Sigma Chemical Co (St.
Animals were kept fasted for 12 hours to potentiate the toxic effect of alloxan. Diabetes was induced by giving single intravenous injection of alloxan in the dorsal tail vein.
Out of 26 female mice selected for the study, a group of 13 were injected with alloxan hydrate to induce diabetes (DM) and the other group of 13 were used as non-diabetic (non-DM) controls.
Bai, "Effect of Gymnema montanum leaves on serum and tissue lipids in alloxan diabetic rats," Experimental Diabesity Research, vol.
Adult male rats (n = 18) weighing 200 [+ or -] 20 g were placed into the following three random groups: control rats, alloxan monohydrated-induced diabetic rats (150 mg/kg intraperitoneally), and BV treated rats (0.5 mg/kg).
Diabetes was induced by a single intraperitoneal injection of alloxan (ALX) at a concentration of 200 mg/kg of body weight.