allotype


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Related to allotype: idiotype

al·lo·type

(al'ō-tīp),
Any one of the genetically determined antigenic differences within an immunoglobulin isotope that occur among members of the same species.
See also: antibody.
Synonym(s): allotypic marker
[allo- + G. typos, model]

allotype

/al·lo·type/ (al´o-tīp) any of several allelic variants of a protein that are characterized by antigenic differences.alloty´pic

allotype

(ăl′ə-tīp′)
n.
1. A biological specimen that is the opposite sex of a holotype.
2. Immunology Any of the alleles in the constant region of a given subclass of immunoglobulin that are detectable as antigens by members of the same species having a different constant region.

al′lo·typ′ic (-tĭp′ĭk) adj.
al′lo·ty′py (-tī′pē) n.

allotype

Immunology
An inherited set of determinants or sequence of amino acids (e.g., on an immunoglobulin—Ig) and other proteins demonstrating heterogeneity, which is specific for an individual and more common in a racial group.

In humans, Ig light-chain allotypes are designated as Km (Inv) allotypes and heavy-chain allotypes as Gm allotypes.

Molecular biology
A protein or other biomolecular variant arising from genetic differences between individuals of the same species.

allotype

An inherited set of determinants or sequence of amino acids–eg, on an Ig–and other proteins demonstrating heterogeneity, which is specific for an individual and more common in a racial group. Cf Idiotype, Isotype.

al·lo·type

(al'ō-tīp)
Any one of the genetically determined antigenic differences within a given class of immunoglobulin that occur among members of the same species.
See also: antibody
[allo- + G. typos, model]

allotype

An allelic variant of an antigen which can prove immunogenic in people with a different version of the allele.

allotype

An allelic variant of an ANTIGEN. Such a variant may elicit an immune response in an apparently normal person.

allotype

one of a range of ANTIBODIES containing different sequences of amino acids but all having an area with an identical amino acid sequence and thought to be produced by different alleles of the same gene (see MULTIPLE ALLELISM).

allotype

a genetically determined variation in plasma proteins which may be recognized as antigenic by other members of the same species. Commonly applied to subclasses of immunoglobulins.
References in periodicals archive ?
Increased risk for selective subnormal IgG1 maybe linked to HLA-A and HLAB loci and G1m allotypes.
HLA-Bw4 epitope and HLA-C allotypes are ligands for NK cell receptors KIR3DL1/3DS1 and KIR2DL1/2DL2/2DL3, respectively (34) and stimulate its cytotoxic activity that is complementary to CTL responses.
The holotype, allotype, and morphotype are deposited at the National Museum of Natural History, Smithsonian Institution, Washington, D.
These comparisons identify specific characteristics in the vicinity of the antigen-binding pocket that distinguish the different HLA-DP allotypes originate from the shape, specific disposition, and variation in the negatively charged groups around the pocket.
The holotype, allotype and paratypes of this species were all collected on Santa Rosa Island, Florida by H.
For example, consider the extreme case in which all individual genotypes rejected all other genotypes: all genotypes would have the same pattern of allorecognition response, yet none would have the same allotype.
1996, Pattan Gar Maharaja (near river Chenab), Shorkot City, District Jhang, 30o 50'N, 72o 04'E; allotype , same data as holotype; 1 , 3 Imm Phoenix dactylifera, jerring, Mukhtar, 28.
A-B, Male holotype, dorsal and ventral; C-D, female allotype, dorsal and ventral.
The holotype male and allotype female were sampled by sweeping grassland.
Bisalbuminemia is usually caused by an albumin variant that differs from the most common allotype, albumin A, by a single amino acid residue, thereby producing 2 albumin fractions of equal or unequal amounts.
MNCN); allotype female: same data (MNCN); paratypes: 1 male, 1 female, Salamanca, Martinamor (Cuatro Calzadas) (40[degrees]49'N, 5[degrees]38'W) 900 m, Holm Oak wood, pt, 8 September 1984, J.