allosteric

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Related to allosterically: gluconeogenesis

allosteric

 [al″o-ster´ik]
pertaining to an effect produced on the biological function of a protein by a compound not directly involved in that function (an allosteric effector) or to regulation of an enzyme involving cooperativity between multiple binding sites (allosteric sites).
allosteric site that subunit of an enzyme molecule which binds with a nonsubstrate molecule, inducing a change in form or shape that results in inactivation of the enzyme for its substrate.

al·lo·ste·ric

(al'ō-ster'ik),
Pertaining to or characterized by allosterism.

allosteric

(ăl′ə-stĕr′ĭk)
adj.
Of or relating to the binding of a molecule to an enzyme at a site other than the active site, resulting in modulation of the enzyme's activity as a result of a change in its shape.

al′lo·ster′i·cal·ly adv.
al·los′ter·y (ə-lŏs′tə-rē) n.

allosteric

Biochemistry
adjective
(1) Referring to allostery, see there.
(2) Referring to the alteration of a binding site on a protein, usually an enzyme, due to interaction with another molecule.
 
Molecular biology
adjective Referring to the stereospecific modification of a protein by an effector to influence other protein- or nucleic acid-binding site activity.

al·lo·ste·ric

(al'ō-ster'ik)
Pertaining to or characterized by allosterism.
References in periodicals archive ?
For instance, riboswitches that are found in the 5'-untranslated region of the Salmonella typhimurium transcription, which is conserved among Gram-negative enteric bacteria, are allosterically activated by [Mn.sup.2+], rather than by [Ca.sup.2+] or [Mg.sup.2+] [25].
Furthermore, AMP binds to nucleotide binding sites on [gamma]-subunits to allosterically activate as well as facilitate Thr172 phosphorylation.
The basis of the mechanism of action of benzodiazepines (BZD), of which the reference representative drug is diazepam (DZ), is their ability to allosterically modulate GABAA receptors, thereby amplifying the effects of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the central nervous system (CNS) [2].
FA2 is one of the high affinity sites for FAs and communicates allosterically with cobalt binding to sites A/B.
TCF3-dependent upregulation of OCT4 allosterically binds to TCF/LEF, preventing [beta]-catenin from binding, which attenuates WNT signaling and differentiation.
In the presence of ADP, the binding affinity for cytochrome c to COX is increased by fivefold as compared to that of ATP, indicating that enzyme activity is modulated allosterically by the ATP/ADP ratio [67-69].
Lee et al., "Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain," Experimental & Molecular Medicine, vol.
Additionally, vanillin can allosterically modulate the GABAergic neurotransmission by enhancing the binding of the endogenous receptor agonist (Ha et al., 2001).
According to the company, CpAMs are direct-acting antivirals that allosterically modulate core protein.
Because the distance between the ATP-binding site and the actin-binding site is 4 nm, the effect of ATP binding is transferred allosterically to the actin-binding site.
The high- and low-affinity receptor binding sites of GH are reportedly allosterically coupled (Walsh et al., 2004); GH first binds to one receptor molecule via site 1 (high affinity), which allosterically affects site 2.
Ethanol allosterically potentiates the action of GABA, or any other activator of this receptor as benzodiazepines or barbiturates, stimulating the flow of chloride induced by these [GABA.sub.A] receptors (Aguayo, Peoples, Yeh & Yevenes, 2002; Grobin et al., 1998).