allosteric transition


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allosteric transition

The reversible modification of a protein’s conformation and function by an effector molecule that binds at a site other than the active site (e.g., through non-competitive receptor inhibition).
References in periodicals archive ?
Changeux, 1965, "On the Nature of Allosteric Transitions: a Plausible Model", Journal of Molecular Biology, no.
[9.] Monod, J, Wyman, J and Changeux, J-P, "On the nature of allosteric transitions: a plausible model", Journal of Molecular Biology 1965; 12: 88-118.
He adds that the technique could be applied not only to protein folding intermediates, but any conformational change in proteins including allosteric transitions and macromolecular assembly.