This suggests that p,p'-DDT may interact with allosteric sites
on the FSHR.
137) It is reasonable to assume that allosteric modulators and allosteric activators are subtype-specific because allosteric sites are not the sites of physiological ligands and thus are not conserved, in contrast with the orthosteric site.
2] receptors indicated that the allosteric sites include amino acid residues in the E2 loop and the aminoterminal end of TM7.
The structures of allosteric sites have been reported for [M.
In order to increase inhibitor selectivity toward a desired target kinase, the focus has turned to developing inhibitors which bind to inactive conformations or allosteric sites.
Using meta-dynamics calculations we propose to investigate the binding mechanisms of inhibitors which target the inactive conformation and allosteric sites.
The approach has enabled the advancement of numerous "stalled" programs by identifying new protein forms and novel binding sites including competitive and allosteric sites
on enzymes and hotspots for protein-protein interactions.
may offer an improved safety profile over ATP site inhibitors as well as provide a dual mode of action.