allosteric sites

allosteric sites

[al′ōster′ik]
Etymology: Gk, allos + stereos, solid
the sites, other than the active site or sites, of an enzyme that bind regulatory molecules.
References in periodicals archive ?
This suggests that p,p'-DDT may interact with allosteric sites on the FSHR.
137) It is reasonable to assume that allosteric modulators and allosteric activators are subtype-specific because allosteric sites are not the sites of physiological ligands and thus are not conserved, in contrast with the orthosteric site.
2] receptors indicated that the allosteric sites include amino acid residues in the E2 loop and the aminoterminal end of TM7.
The structures of allosteric sites have been reported for [M.
In order to increase inhibitor selectivity toward a desired target kinase, the focus has turned to developing inhibitors which bind to inactive conformations or allosteric sites.
Using meta-dynamics calculations we propose to investigate the binding mechanisms of inhibitors which target the inactive conformation and allosteric sites.