allosteric inhibitors

allosteric inhibitors

substances which prevent an enzyme from changing into an active form by combining not with the ACTIVE SITE but with some other part of the enzyme.
References in periodicals archive ?
HotSpot's lead compounds include the first and only allosteric inhibitors to target PKC-theta for autoimmune diseases, and S6 kinase, an immuno-metabolic enzyme involved in the regulation of hepatic insulin sensitivity and mitochondrial function - an important new target for NASH and metabolic diseases.
Tetra uses structure-guided drug design to discover mechanistically novel, allosteric inhibitors of phosphodiesterase 4, an enzyme family that plays key roles in memory formation, learning, neuroinflammation, and traumatic brain injury.
The company uses structure-guided drug design to discover mechanistically novel, allosteric inhibitors of phosphodiesterase 4, an enzyme family that plays key roles in memory formation, learning, neuroinflammation, and traumatic brain injury.
reported that allosteric inhibitors could occupy an adaptable part and stabilize a conformation that was associated with the open form of PTP1B.
The 10th Drug Design & Medicinal Chemistry Conference brings together a mix of academic and industry authoritative experts from leading affiliations (Sanofi-Aventis, Roche, Vernalis, Heptares Therapeutics, Boehringer-Ingelheim, etc.) to cover many current and relevant aspects of protein-protein interactions, overcoming resistance in drug design, and allosteric inhibitors.
Instead, this new class, called allosteric inhibitors, changes the shape of the target enzyme and in doing so, renders it inactive.
The reversible Hill equation is widely used to model the kinetics of biochemical reaction networks with allosteric inhibitors and/or activators.