allosteric


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Related to allosteric: allosteric site

allosteric

 [al″o-ster´ik]
pertaining to an effect produced on the biological function of a protein by a compound not directly involved in that function (an allosteric effector) or to regulation of an enzyme involving cooperativity between multiple binding sites (allosteric sites).
allosteric site that subunit of an enzyme molecule which binds with a nonsubstrate molecule, inducing a change in form or shape that results in inactivation of the enzyme for its substrate.

al·lo·ste·ric

(al'ō-ster'ik),
Pertaining to or characterized by allosterism.

allosteric

(ăl′ə-stĕr′ĭk)
adj.
Of or relating to the binding of a molecule to an enzyme at a site other than the active site, resulting in modulation of the enzyme's activity as a result of a change in its shape.

al′lo·ster′i·cal·ly adv.
al·los′ter·y (ə-lŏs′tə-rē) n.

allosteric

Biochemistry
adjective
(1) Referring to allostery, see there.
(2) Referring to the alteration of a binding site on a protein, usually an enzyme, due to interaction with another molecule.
 
Molecular biology
adjective Referring to the stereospecific modification of a protein by an effector to influence other protein- or nucleic acid-binding site activity.

al·lo·ste·ric

(al'ō-ster'ik)
Pertaining to or characterized by allosterism.
References in periodicals archive ?
Since CBS is normally activated by AdoMet, it is natural that the steady-state of the system is entirely influenced by this allosteric regulation.
Since some of these enzymes fuction as allosteric modifies in intra-cellular reactions, the fluctuations inevitably affect these reactions [13,14].
Various indications can be found in earlier papers about the significant role of the allosteric cooperativity in ligand binding with protein kinase A.
Eisenstein, Structure and Control of Pyridoxal Phosphate-Dependent Allosteric Threonine Deaminase, Structure 6 (4), 465-475 (1998).
This mutation causes aberrations in the allosteric properties of globin.
'We are excited to be joining forces with the HotSpot team to develop new allosteric medicines.'
Beactica's allosteric LSD1 modulators have also shown efficacy in models of treatment-resistant glioblastoma.
Our aim is to identify compounds that modulate the properties of these receptors but do so by binding to an allosteric site.
The company uses structure-guided drug design to discover mechanistically novel, allosteric inhibitors of phosphodiesterase 4, an enzyme family that plays key roles in memory formation, learning, neuroinflammation, and traumatic brain injury.
Targeting scientists looking to understand the practice of fragment-based drug discovery (FBDD), Howard and Abell provide experts from the areas of epigenetics, G protein-coupled receptors (GPCRs), protein-protein interactions, antibacterials and identification of novel allosteric binding pockets, and discuss lessons learned based on experience and key examples from the literature.
The 2nd Kinase Inhibitors Design & Screening Conference brings together a mix of academic and industry authoritative experts from leading affiliations (Novartis, Barts Cancer Institute, Genentech, Sanofi-Aventis, Schrodinger, Netherlands Translational Research Center, etc.) to cover many current and relevant aspects of allosteric kinase inhibitors, covalent inhibitor strategies, irreversible and RAF inhibitors, mechanisms of kinase inhibitor resistance, and mutation-focused approaches towards kinase inhibition.
Their topics include a natural history of sensor domains in bacterial signaling systems, sensing ligands by periplasmic sensing histidine kinases with sensory pas domains, bacterial chemoreceptors as membrane-spanning allosteric enzymes, metal-dependent and metal responsive regulatory systems, and thiol-based sensory factors.