allosensitization

al·lo·sen·si·ti·za·tion

(al'ō-sen'si-ti-zā'shun),
Exposure to an alloantigen that induces immunologic memory cells.
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References in periodicals archive ?
This finding is in agreement with previous reports that RBC allosensitization is more likely in patients with increased frequency of blood transfusion [3436].
Frequency of Red Blood Cell Alloimmunization in Patients with Sickle Cell Disease in Palestine
The potential advantage of these cells over other stem cell types studied to date is that they are immunoprivileged and thus do not cause the activation of immune response and allosensitization, which enables them to be used in an allogeneic setting.
Stem Cell Therapy in Patients with Chronic Nonischemic Heart Failure
Ricordi et al., "Allosensitization of islet allograft recipients," Transplantation, vol.
The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions
RH variant alleles may encode Rh proteins with amino acid changes that cannot be distinguished with common serologic reagents (eg, V, VS, Goa) but can result in allosensitization upon exposure in an individual lacking the variant allele.
Genotyping Applications for Transplantation and Transfusion Management The Emory Experience
This leads to the formation of neovessels and neolymphatics, which further facilitate the trafficking of mature APCs to the cornea and to draining lymph nodes, where priming of naive T cells or allosensitization occurs [8].
Effector and Regulatory T Cell Trafficking in Corneal Allograft Rejection
Allosensitization rate of male patients awaiting first kidney grafts after leuko-depleted blood transfusion.
Analysis of platelet eluate for the elucidation of sensitization to HLA in kidney transplant candidate/Analise do eluato de plaqueta para a elucidacao da sensibilizacao ao HLA em um candidato ao transplante de rim
--decreased rate of immunization and allosensitization (10 percent vs 30 percent in controls)
Improved outcomes using mesenchymal precursor cells in end-stage heart failure
Additionally, frequent blood transfusions increased the patient's risk for allosensitization and decreased the chances for identifying a matched donor kidney (Eady, 2008).
Erythropoiesis-stimulating agents for the management of anemia of chronic kidney disease: past advancements and current innovations
Patients have a lifelong tendency toward bleeding and chronic anemia with increased risk for blood transfusion due to hepatitis or allosensitization.
Diseases of the gut may present cutaneously
Re-transplantation occurs in up to 25% of patients requiring renal replacement therapy.[sup.14] This paper highlights the importance of minimizing the extent of allosensitization in renal transplant patients to not only maximize the lifespan of the allograft, but also to abrogate the potentially detrimental immunological effects of a failed graft on re-transplantability.
Early but not late allograft nephrectomy reduces allosensitization after transplant failure
*There is insufficient evidence to conclude that the presence of B and/or T cell allosensitization (e.g.
Xenotransplantation should go forward if current animal studies achieve acceptable results-ISHLT
Transfusion is poorly immunogenic [62], and multiple transfusions are required to induce persistent HLA allosensitization [67].
Kidney Transplantation: The Challenge of Human Leukocyte Antigen and Its Therapeutic Strategies

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