RH variant alleles may encode Rh proteins with amino acid changes that cannot be distinguished with common serologic reagents (eg, V, VS, Goa) but can result in allosensitization upon exposure in an individual lacking the variant allele.
Allosensitization in patients receiving multiple blood transfusions.
Allosensitization rate of male patients awaiting first kidney grafts after leuko-depleted blood transfusion.
decreased rate of immunization and
allosensitization (10 percent vs 30 percent in controls)
Additionally, frequent blood transfusions increased the patient's risk for
allosensitization and decreased the chances for identifying a matched donor kidney (Eady, 2008).
Patients have a lifelong tendency toward bleeding and chronic anemia with increased risk for blood transfusion due to hepatitis or
allosensitization.
1,2] Unfortunately, allosensitization presents a considerable barrier to re-transplantation in these patients.
2,12] Surprisingly, the effects of this widely accepted strategy on allosensitization are not well-documented.
There is insufficient evidence to conclude that the presence of B and/or T cell
allosensitization (e.
The immunologic impact of the AN was evaluated by using the change in percentage of the panel reactive antibody (%PRA) as a surrogate marker for allosensitization.
5] The factors driving increased allosensitization post-AN are unclear.
A:
Allosensitization is an important concept in the nephrology/transplant community.
