alloreactive

alloreactive

(al″ō-rē-ak′tiv) [ allo- + reactive]
Pert. to certain classes of T lymphocytes, immunologically reactive against a transplanted tissue or organ.
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References in periodicals archive ?
The product's CaspaCIDe safety switch enables this approach by allowing physicians to reduce the number of alloreactive cells in the event of uncontrolled GvHD.
Bellicum Pharmaceuticals Reports Second Quarter 2019 Financial Results and Provides Operational Update
This results in selectively depleting more GvHD-causing rivo-cel cells while sparing less alloreactive rivo-cel cells to continue to provide immunity and graft versus leukemia effect.
Bellicum announces interim results showing rimiducid controlled GvHD
High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response.
Neutrophil Extracellular Traps in Autoimmune Diseases
Human mesenchymal stem cells require monocytc-mediated activation to suppress alloreactive T cells.
Menstrual Blood-Derived Stromal Stem Cells Augment CD4+ T Cells Proliferation
Simultaneous liver-kidney transplant recipients had significantly lower frequency of interferon-gamma-producing alloreactive T cells than solitary kidney transplant recipients.
Liver-Kidney Recipients Have Donor-Specific Hypo-Responses; Unique characteristics ID'd in peripheral blood cells of simultaneous liver-kidney transplant recipients
It is designed to provide a safety net to eliminate alloreactive BPX-501 T cells (via administration of activator agent rimiducid) should uncontrollable GvHD or other T-cell mediated transplant complications occur.
FDA Lifts Clinical Hold On U.S. Studies off T-Cell Therapy
Data generated from murine models propose that these conditioning agents produce lung epithelial injury followed by excessive requirement and activation of pulmonary macrophages and alloreactive T-lymphocytes (21).
Current Approach to Non-Infectious Pulmonary Complications of Hematopoietic Stem Cell Transplantation
Alloreactive [CD3.sup.+] T cells (5 x [10.sup.5] cells/well) from the spleen of BALB/c mice were used as responders, and splenic [CD11c.sup.+] DCs (5 x [10.sup.4] cells/well) from B6 recipients were used as stimulators.
B7-H1 Expression Is Required for Human Endometrial Regenerative Cells in the Prevention of Transplant Vasculopathy in Mice
Adorini, "1[alpha],25-Dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation," Journal of Immunology, vol.
Vitamin D Ameliorates Impaired Wound Healing in Streptozotocin-Induced Diabetic Mice by Suppressing Endoplasmic Reticulum Stress
Kronke, "Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes," Nature Medicine, vol.
Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD
Larkin, "Aqueous humor alloreactive cell phenotypes, cytokines and chemokines in corneal allograft rejection," American Journal of Transplantation, vol.
The Balance of Th1/Th2 and LAP+Tregs/Th17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation
Finally, blockade of CD73 induced the expansion of alloreactive T cells, which exacerbated GvHD and enhanced the graft-versus-tumor effect.
The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases

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