However, histologically proven iTMA has been documented in both the autologous stem cell and solid organ transplant settings, where an
alloreactive T-cell-mediated GVHD is highly unlikely.
De novo DSAs seem to appear in approximately one-fourth of the patients after transplantation as a result of
alloreactive humoral responses and are associated with increased incidence of CR and graft loss.
Doherty, "HumanV[delta]2+[gamma][delta] T cells differentially induce maturation, cytokine production, and
alloreactive T cell stimulation by dendritic cells and B cells," Frontiers in Immunology, vol.
The following system models the dynamics of tumor cells (T), cancer stem cells (S),
alloreactive cytotoxic-T-lymphocytes (C), TGF-[beta] ([F.
At the same time, MSCs express low levels of MHC class I and no MHC class 2 and costimulatory molecules CD40, CD80, and CD86, preventing
alloreactive antibody production and destruction [25, 26].
However, Ueta et al showed that
alloreactive T cell synthesis of both Thl (IL-2 and IFN-[gamma]) and Th2 (IL-6 and IL-10) type cytokine significantly decreased in the presence of amniotic membrane (AM) when AM was added to MLR culture well (25).
Reduced
alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated 11-10, IL-13, and decreased IFNgamma levels.
Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of
alloreactive NK cells.
Although cGVHD is a systemic condition mediated by
alloreactive donor-derived lymphocytes, the clinical impact and associated morbidity are typically experienced at the level of the individual target organ, where localized and anatomically distinct immune activity (eg, mucosal immunity) may play a major pathogenic role in mediating disease activity.
It is thought that both donor-derived
alloreactive T cells similar to AGVHD and autoreactive T cell clones which can not be deleted as a result of thymic damage are involved (66, 67).
Retrovirus-mediated transfer of the herpes simplex type I thymidine kinase gene in
alloreactive T lymphocytes.
The immunological monitoring of
alloreactive responses in liver transplant recipients: a review.
