The product's CaspaCIDe safety switch enables this approach by allowing physicians to reduce the number of
alloreactive cells in the event of uncontrolled GvHD.
This results in selectively depleting more GvHD-causing rivo-cel cells while sparing less
alloreactive rivo-cel cells to continue to provide immunity and graft versus leukemia effect.
High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17
alloreactive response.
Human mesenchymal stem cells require monocytc-mediated activation to suppress
alloreactive T cells.
Simultaneous liver-kidney transplant recipients had significantly lower frequency of interferon-gamma-producing
alloreactive T cells than solitary kidney transplant recipients.
It is designed to provide a safety net to eliminate
alloreactive BPX-501 T cells (via administration of activator agent rimiducid) should uncontrollable GvHD or other T-cell mediated transplant complications occur.
Data generated from murine models propose that these conditioning agents produce lung epithelial injury followed by excessive requirement and activation of pulmonary macrophages and
alloreactive T-lymphocytes (21).
Alloreactive [CD3.sup.+] T cells (5 x [10.sup.5] cells/well) from the spleen of BALB/c mice were used as responders, and splenic [CD11c.sup.+] DCs (5 x [10.sup.4] cells/well) from B6 recipients were used as stimulators.
Adorini, "1[alpha],25-Dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired
alloreactive T cell activation," Journal of Immunology, vol.
Kronke, "Soluble HLA class I molecules induce apoptosis in
alloreactive cytotoxic T lymphocytes," Nature Medicine, vol.
Larkin, "Aqueous humor
alloreactive cell phenotypes, cytokines and chemokines in corneal allograft rejection," American Journal of Transplantation, vol.
Finally, blockade of CD73 induced the expansion of
alloreactive T cells, which exacerbated GvHD and enhanced the graft-versus-tumor effect.