The product's CaspaCIDe safety switch enables this approach by allowing physicians to reduce the number of alloreactive
cells in the event of uncontrolled GvHD.
This results in selectively depleting more GvHD-causing rivo-cel cells while sparing less alloreactive
rivo-cel cells to continue to provide immunity and graft versus leukemia effect.
High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive
Human mesenchymal stem cells require monocytc-mediated activation to suppress alloreactive
Simultaneous liver-kidney transplant recipients had significantly lower frequency of interferon-gamma-producing alloreactive
T cells than solitary kidney transplant recipients.
It is designed to provide a safety net to eliminate alloreactive
BPX-501 T cells (via administration of activator agent rimiducid) should uncontrollable GvHD or other T-cell mediated transplant complications occur.
Data generated from murine models propose that these conditioning agents produce lung epithelial injury followed by excessive requirement and activation of pulmonary macrophages and alloreactive
[CD3.sup.+] T cells (5 x [10.sup.5] cells/well) from the spleen of BALB/c mice were used as responders, and splenic [CD11c.sup.+] DCs (5 x [10.sup.4] cells/well) from B6 recipients were used as stimulators.
Adorini, "1[alpha],25-Dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive
T cell activation," Journal of Immunology, vol.
Kronke, "Soluble HLA class I molecules induce apoptosis in alloreactive
cytotoxic T lymphocytes," Nature Medicine, vol.
Larkin, "Aqueous humor alloreactive
cell phenotypes, cytokines and chemokines in corneal allograft rejection," American Journal of Transplantation, vol.
Finally, blockade of CD73 induced the expansion of alloreactive
T cells, which exacerbated GvHD and enhanced the graft-versus-tumor effect.