However, the thermal hyperalgesia and tactile allodynia
are completely suppressed by repeated intrathecal injection of the TrkB protein, which sequesters endogenous brain-derived neurotrophic factor (BDNF) (99).
(8) In the rat, gabapentin was shown to inhibit allodynia
in a dose-dependent fashion between 10 mg/kg and 100mg/kg.
Significant reduction in paw withdrawal and cold allodynia
thresholds confirms nocifensive behavioural and hyperalgesic effect.
Typically, the pain experienced by patients with CRPS type-1 can be elicited by movements of the involved joints (deep somatic allodynia
) even when these joints are not directly involved in the initial inciting injury.21 The spontaneous pain and various forms of allodynia
experienced are thought to be generated by processes of peripheral and central sensitization.
In our patients, no signs of hyperalgesia or allodynia
Hyperalgesia and allodynia
are frequently present or develop later in the course of illness.
denotes the perception of pain or discomfort induced by a nonnoxious stimuli such as touching, combing hair, or wearing eyeglasses which are not expected to elicit pain.
In our previous study, we found that PDE2A was significantly increased in the spinal cord of chronic radiculitis rats and was dramatically inhibited by the PDE2A inhibitor, BAY 60-7550, which decreased the spinal tumor necrosis factor- (TNF-) [alpha], interleukin- (IL-) 1[beta], and IL-6 levels and also alleviated radiculitis and mechanical allodynia
in noncompressive lumbar disc herniation (NCLDH) rats .
was assessed using an electronic von Frey device (series 2390; IITC Life Science Inc., Woodland Hills, CA), as described by Mitrirattanakul et al.
In a preclinical model of cisplatin-induced peripheral neuropathy, the highly selective HDAC6 inhibitor, ACY-1083, was shown to prevent and reverse pain in response to touch, known as mechanical allodynia
However, gabapentin can interact with several targets, including the [alpha]2-[delta] subunit of voltage-activated calcium channels  and the L-amino acid transporters (LAT-1 and LAT-2; ) and has been shown to reduce spinal microglial activation and allodynia
in rats with experimental diabetes [11,12].