Liu et al., "Quality assessment of reporting of randomization, allocation concealment
, and blinding in traditional Chinese medicine RCTs: a review of 3159 RCTs identified from 260 systematic reviews," Trials, vol.
The main biases were blinding, allocation concealment
, and similarity of treatment groups at baseline.
Certainly the included items were on the whole the more important ones, but there were a few notable omissions, such as "Bland-Altman method", "Allocation concealment
" and "Linear mixed model".
A total of 76 patients (93.5%) with confirmed capsular or labral injury randomly received (allocation concealment
uncertain) either open surgical repair or conservative therapy (immobilization in a fixed sling for 2 days, followed by a nonfixed sling for 1 week).
Double-blinding was used in eight studies but adequate allocation concealment
was clearly described in only four studies (10, 11,16,17).
(1) The quality of the studies was generally low due to inadequate allocation concealment
, lack of blinding of outcome assessors, loss to follow-up, and the small number of participants in trials.
Following 6-week treatment of the ulcer, the 242 patients were randomly assigned (allocation concealment
uncertain) to receive 6 months of treatment with either celecoxib 200 mg daily or naproxen 250 mg 3 times daily with lansoprazole 30 mg daily.
Subjects were randomized (uncertain allocation concealment
) to receive 3 days of amoxicillin-clavulanate 500 mg/125 mg twice daily, or ciprofloxacin 250 mg twice daily.
The patients were randomized (allocation concealment
uncertain) to receive either placebo or bupropion 150 mg twice daily for 7 weeks.
The children were randomized (allocation concealment
uncertain) to receive a single dose of placebo, diphenhydramine (Diphen), or dextromethorphan (Benylin), for the single night of the study.
Groups were balanced at the start of the study, analysis was by intention to treat, but allocation concealment
was not described.
Trials were individually assessed for adequacy of allocation concealment
and blinding of individuals assessing outcomes.