alloantigen


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al·lo·an·ti·gen

(al'ō-an'ti-jen),
An antigen that occurs in some but not all members of the same species. Used by the immune system to distinguish self from nonself.

alloantigen

/al·lo·an·ti·gen/ (-an´tĭ-jen) an antigen present in allelic forms encoded at the same gene locus in different individuals of the same species.

alloantigen

(ăl′ō-ăn′tĭ-jən)

alloantigen

alloantigen

An antigen that occurs in some members of a species, which in humans is determined in part by the major histocompatibility complex.

al·lo·an·ti·gen

(al'ō-an'ti-jen)
An antigen that occurs in some, but not in other members of the same species. The term isoantigen is sometimes used in this sense.

alloantigen

an antigen existing in alternative (allelic) forms in a species, thus inducing an immune response when one form is transferred to members of the species who lack it; typical alloantigens are the blood group antigens.

canine secretory alloantigen system (CSA)
a minor histocompatibility system in dogs.
References in periodicals archive ?
The results shown above suggest that tolerant T or B cells can be reinvigorated by alloantigen stimulation under PD-1/PD-L1 blockade.
We found that tolerant mice failed to produce any levels of antibodies against alloantigens upon two weekly alloantigen challenges (Figure 1).
We found that the tolerance was transferrable with adoptive CD4+ T cell transfer to syngeneic naive recipient mice, showing that mice receiving CD4+ T cells from tolerant mice failed to produce antibodies against alloantigens upon alloantigen challenge (Figure 2).
Administration of ethylene carbodiimide- (ECDI-) fixed allogeneic splenocytes failed to induce alloantigen tolerance in PD-L1 deficient mice, suggesting that PD-1/PD-L1 is required for alloantigen tolerance induced by ECDI-treated allogeneic splenocytes [11].
Finally, we investigated how the tolerance state in tolerant mice affected alloantigen-responding T cells that never experienced alloantigens and whether PD-1/PD-L1 interaction was also involved in this process.
Caption: Figure 2: Alloantigen immune tolerance is transferable by adoptive transfer of CD4+ T cells from long-lasting tolerant mice.
2] integrin subunit leads to the formation of new human platelet alloantigen [Sit.
2]-Terminal globular domain of human platelet glycoprotein Ib[alpha] has a methionine 145/threonine 145 amino acid polymorphism, which is associated with the HPA-2 (Ko) alloantigens.
The human platelet alloantigens Br(a) and Br(b) are associated with a single amino acid polymorphism on glycoprotein la (integrin subunit [[alpha].