The mean age of patients who developed red cell alloantibody
Initial monitoring is performed by antenatal titrations to determine if the titre of the alloantibody
is increasing or is greater than or equal to 16.
4% AA: Alloantibody
, CSAA: Clinically significant alloantibody
, MA: Maternal antibodies
Investigations of the alloantibody
specificity detected the Rh Group to be the most common (63.
One study of a group of cancer patients showed that approximately 9% formed alloantibodies and that risk of developing alloantibody
Clinical and Laboratory Standards Institute (CLSI) has recently published a new document, Detection of HLA-Specific Alloantibody
by Flow Cytometry and Solid Phase Assays; Proposed Guideline (I/LA29-P), which describes criteria for optimizing flow cytometry crossmatching and the detection of HLA alloantibody
by solid-phase methods in conventional and multiplex platforms.
A DAT can detect immunotargeting of transfused RBCs before hemolysis is clinically evident, or it can confirm the presence of an alloantibody
in suspected hemolytic transfusion reactions.
Antibody screen positive samples were further analysed for the specificity of the alloantibody
with an eleven cell identification panel (Matrix gel system & Matrix Erygen ID, Tulip Diagnostics, India).
In most cases, an IgG alloantibody
or autoantibody arises in response to the drug or a drug-platelet protein complex.
Recently transfused cells may not have all antigens fully saturated with antibody, and additional absorption of alloantibody
might take place with prolonged storage.
To assess risk for HDFN, if the mother has a clinically significant alloantibody
, ABT is performed.
Anti-Diego' red blood cell alloantibody
as a possible cause of anemia in a 3-week old infant.