Survival differences were compared in recipients without detectable
alloantibodies and those with de novo and pre-existing
alloantibodies and in those recipients with and those without detectable BKV.
Antenatal first trimester screening enables timely detection of
alloantibodies and treatment of HDFN, and an additional benefit of the screening program is the detection of
alloantibodies relevant in case of transfusion to the mother.
Nine patients (7.76%) developed
alloantibodies and 107 (92.24%) did not.
The destructive power of
alloantibodies of the recipients directed against HLA class I and II molecules varies [112], depending on the level of antibody [33], immunoglobulin isotype, target antigen, and the type of organ transplanted [117, 118].
In addition, a survey ascertained that female dogs, even after pregnancy, did not develop any
alloantibodies against RBC antigens during gestation, so they can be used safely as blood donors [40].
In conclusion, screening for HLA and HPA
alloantibodies is an important adjunctive laboratory test in the diagnosis of platelet refractoriness.
[11] Kalluri, R., Weber, M., Netzer, K.O., Sun, M.J., Neilson, E.G., and Hudson, B.G., COL4A5 gene deletion and production of post-transplant anti-alpha-3(IV) collagen
alloantibodies in Alport syndrome.
Sensitization to human leukocyte antigens (HLA) in transplant immunology is the occurrence of
alloantibodies in the serum of patients who desire to receive organs, directed towards HLA antigens.
Screening and identifying of erythrocyte
alloantibodies in patients with Thalassemia major referred to Ahvaz Shafa hospital.
the identification of platelet
alloantibodies and for platelet-specific autoantibodies detection7.
Preand post-transfusion and follow-up testing did not show evidence of red blood cell
alloantibodies, making the possibility of a delayed hemolytic transfusion reaction unlikely.
It is thought that hemolytic anemia is related with erythrocyte
alloantibodies (anti-A, anti-B and anti-D) found in IVIG preperation (16-18).
