ATRA

(redirected from all-transretinoic acid)

ATRA

A vitamin-A analogue used to manage acute promelocytic leukaemia, with the translocation t(15;17) or typical PML-RAR gene rearrangement, as it prompts the leukaemic cells to maturation.

Adverse effects
Headaches, dry skin, mouth and eyes, nausea, bone pain.
References in periodicals archive ?
Pediatric acute promyelocytic leukemia: all-transretinoic acid therapy in a Brazilian pediatric hospital.
7] M all-transretinoic acid decreased the expression of MMP-9, and combined treatment with both all-trans-retinoic acid and P.
Hydroxypinacolone Retinoate is the cosmetic ester of all-transretinoic acid and, unlike retinol esters, does not require metabolic conversion to be in the preferred active form for interacting with retinoic RAR receptors to obtain benefits of vitamin A.
Phytanic acid and docosahexaenoic acid increase the metabolism of all-transretinoic acid and CYP26 gene expression in intestinal cells.
The patient was treated with high-dose all-transretinoic acid for 14 days, followed by a first induction chemotherapy regimen consisting of cytarabine, daunorubicine, and thioguanine.
There are two classes of retinoid receptor, the RAR or retinoic acid receptor, which binds all-transretinoic acid, and RXR, or the so-called orphan receptor whose ligand is believed to be 9-cis-retinoic acid.

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