reported a role of in situ click chemistry to explain bio-orthogonal 1,3-dipolar cycloaddition of azide and alkynes
in HIV-1-Pr inhibition .
Dinsmore, "Rhodium(II) acetate catalyzed alkyne
insertion reactions of.alpha.-diazo ketones: mechanistic inferences," Journal of the American Chemical Society, vol.
As it can be seen from the results of electrophoresis, Taq polymerase is capable to effectively incorporate in the sequence of a strand only modified nucleotide 5-(C8 Alkyne
Van Horn discovered the alkyne
version of Zr-catalyzed carboalumination in 1978.
His group's latest innovation, published in the Journal of the American Chemical Society, makes use of molecules with a diazonium group on one end, and alkyne
(C [equivalent to] CH) groups on the other.
E-BODIPY compounds offer the potential for further modification when the substituting nucleophile is an ethynyl group, including nucleophilic addition to and polymerization of the compound at the alkyne
site (Goze et al.
The product of oxidative addition reacts with alkyne
in the presence of base resulting in the [PdL.sub.2](PhCC)Ph complex.
The CuAAC click reaction between an azide and alkyne
takes place in presence of a Cu (I) catalyst under mild conditions resulting in the formation of a triazole link connecting two molecules.
These polymers have gained a huge interest academically in recent years as the azide group can undergo a cycloaddition reaction with a terminal alkyne
group in presence of a Cu(I) catalyst to make block, graft, brush, and star polymers.
The contributions describe approaches for conjugating proteins and peptides to polymers, generating complex macromolecular architectures via orthogonal and selective cycloadditions, fabricating alkyne
and azide functionalized surfaces, and designing multifunctional network polymers.
There's a rigid chassis and the four axles (each made of alkyne
) turn freely.
ENYNE a molecule with an alkene and an alkyne