alkylate

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alkylate

 [al´kĭ-lāt]
to cause the substitution of an alkyl group for an active hydrogen atom in an organic compound; see also alkylating agents.

alkylate

(al′kĭ-lāt″)
1. To introduce one or more alkyl groups into a compound.
2. To provide therapy with an alkylating agent.
References in periodicals archive ?
The rise in incidence was attributed to transplantation of older patients, who received multiple therapies including multiple alkylating agents [5].
A study of the stability of three phase-transfer catalysts to afford five different nucleophiles suggests the feasibility of quaternary ammonium salts acting as alkylating agents for certain carbon and sulfur nucleophiles [7] and demonstrates the reaction of thiolate nucleophiles with a catalyst in preference to the substrate.
Table 5 shows the frequency of blood and lymphatic system disorders between patients taking or not alkylating agents, and Table 6 shows the frequency of PN between patients to whom bortezomib was administered iv or sc, excluding patients who were treated with combined bortezomib and thalidomide protocols.
Three small, nonrandomized studies using historical controls suggest some protective effect in patients getting GnRH before alkylating chemotherapy for Hodgkin's disease and non-Hodgkin's lymphoma.
At one TRC member institution, the Massachusetts Institute of Technology (MIT), researchers are focusing their attention on the effects of simple and complex alkylating agents, a class of DNA-damaging environmental toxins and toxicants that cause cell death, mutations, birth defects, and cancer.
Cisplatin falls into the category of chemotherapy agents called alkylating agents.
The anti-neoplastic agent can be an alkylating agent, an antibiotic agent, an antimetabolic agent, a retinoid, a hormonal agent, a plant-derived agent, an anti-angiogenesis agent and a biologic agent such as monoclonal antibody and interferon.
ESP Pharma, Inc., Edison, NJ, announced it has acquired from Orphan Medical, Inc., Minnetonka, MN, worldwide rights to Busulfex Injection, an intravenous formulation of the alkylating agent busulfan, a drug often used in bone marrow transplantation.
Loeb, citing a study in which postpubertal girls treated with either alkylating agents or pelvic radiation had a 2.5 risk ratio of being menopausal 5 years after their treatment, while there was no increased risk in girls treated for cancer prior to puberty.
A humanized monoclonal antibody for treating B-cell chronic lymphocytic leukemia in people who have been treated with alkylating agents and have failed treatment with fludarabine.
(b) A derivative [Hcy-acetylbenzoic acid (Hcy-ABA)] is formed by reacting with the alkylating agent p-(2-chloroacetyl)benzoic acid phosphate (CABA-phosphate); and
He and a team of researchers have developed a way to measure the ability of particular cancer cells to repair the damage done to DNA by a category of commonly utilized anti-cancer drugs that are known as alkylating agents, including nitrosourea and cisplatinin.