alkaline phosphatases

ENZYMES with an optimum pH in the alkaline range, that break down phosphate bonds in compounds. They are widely distributed in the body, and are released into the blood in large quantites in a number of conditions including obstructive JAUNDICE and certain bone diseases. This forms the basis of a common biochemical test.

References in periodicals archive ?

Heat inactivation in the study of human alkaline phosphatases.

Alkaline phosphatase (ALP) isoenzymes mainly exist in bones, liver, intestine, placenta, mammary glands, kidneys, and leukocytes.

Effect of incubation period on measurement of alkaline phosphatase enzyme activity at 37[degrees]C

Alkaline phosphatases (APs) have been continuously and extensively investigated for over 50 years.

Intestinal alkaline phosphatase: potential roles in promoting gut health in weanling piglets and its modulation by feed additives--a review

Involvement of CD36 and intestinal alkaline phosphatases in fatty acid transport in enterocytes, and the response to a high-fat diet.

Intestinal alkaline phosphatase: an enzyme with anti-inflammatory properties/Fosfatasa alcalina intestinal: una enzima con propiedades antiinflamatorias/Fosfatasse alcalina intestinal: uma enzima com propriedades anti-inflamatorias

Alkaline Phosphatases are a group of enzymes found primarily the liver (isoenzyme ALP-1) and bone (isoenzyme ALP-2).

Some differences in parameters of bone mineral metabolism in various sport branches

Total bone and liver alkaline phosphatases in plasma: biological variations and reference limits.

What is the differential diagnosis of an elevated alkaline phosphatase (AP) level in an otherwise asymptomatic patient?

Improved electrophoretic resolution of bone and liver alkaline phosphatases resulting from partial digestion with neuraminidase.

Analytical and clinical performance characteristics of tandem-MP ostase, a new immunoassay for serum bone alkaline phosphatase

Biology of human alkaline phosphatases with special reference to cancer.

Differences of bone alkaline phosphatase isoforms in metastatic bone disease and discrepant effects of clodronate on different skeletal sites indicated by the location of pain

Alkaline phosphatases have been nearly a lifelong labor for George Bowers and Robert McComb.

They use enzymes for everything!

The point in assessing the bone-specific fraction of alkaline phosphatases is to determine whether or not this advances diagnostic sensitivity.

More on total and bone-specific alkaline phosphatase

Osteoblasts are rich in alkaline phosphatase; however, alkaline phosphatase, an enzyme associated with the plasma membrane of cells, is also found in liver, intestine, and placenta (15), all of which may contribute to the total amount of alkaline phosphatase found in blood.

Clinical utility of biochemical markers of bone remodeling

The bone isoform of alkaline phosphatase (ALP) is a member of the so-called tissue-nonspecific isoenzyme family, which also comprises the liver and kidney isoforms.

Direct comparison of performance characteristics of two immunoassays for bone isoform of alkaline phosphatase in serum