alkaline phosphatase isoenzyme


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alkaline phosphatase isoenzyme

Any of the organ-specific alkaline phosphatase isoenzymes: liver, bone, intestine and placenta. Intestinal AP occurs almost exclusively in individuals with blood group B or O and is increased 8 hours after a fatty meal; placental AP first appears in the 2nd trimester of pregnancy, accounts for half of all AP in the 3rd trimester and drops to normal levels 1 month postpartum; the Regan isoenzyme resembles the placental AP and is present in some patients with cancer. APIs should not be measured if the total AP levels are within the lab’s reference range, as the results have little significance; these tests are only semi-quantitative and are variable.

alkaline phosphatase isoenzyme

Clinical chemistry Any of the organ-specific alkaline phosphatase isoenzymes: liver, bone, intestine and placenta; intestinal AP occurs almost exclusively in individuals with blood group B or O and is ↑ 8 hrs after a fatty meal; placental AP first appears in the 2nd trimester of pregnancy, accounts for half of all AP in the 3rd trimester and drops to normal levels 1 month post partum; the Regan isoenzyme resembles the placental AP and is present in some Pts with cancer. See Alkaline phosphatase.
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(13.) Vivane, Van Hoof et al "Alkaline phosphatase isoenzyme patterns in malignant disease "Clinical chemistry 38/12, 2546-2551 (1992).
Krant, M.D "Ectopic Production of an Alkaline Phosphatase Isoenzyme in Patients with Cancer" N Engl J Med 1969; 281:757-762 October 2, 1969.
Alkaline phosphatase isoenzymes in mouse plasma detected by polyacrylamide-gel disk electrophoresis.
A relative heat stability test for the identification of serum alkaline phosphatase isoenzymes. Clin Chim Acta.
The NACB guideline for testing of newborns (7), for example, recommended that testing for alkaline phosphatase isoenzymes not be performed.
The following biochemical indexes were analyzed on freshly collected serum from patients: alpha-fetoprotein (AFP), carcinoembryonic antigen, lactate dehydrogenase (LD), LD isoenzymes, alkaline phosphatase and alkaline phosphatase isoenzymes, [gamma]-glutamyltransferase (GGT) and the GGTL isoenzyme (i.e., GGT complexed to LDL and VLDL), 5'-nucleotidase, leucine aminopeptidase, cholinesterase, copper, iron, ferritin, and pseudouridine, using previously described procedures (2).
Two new methods for separating and quantifying bone and liver alkaline phosphatase isoenzymes in plasma.
Analysis of heat inactivation curves of alkaline phosphatase isoenzymes in serum.
Clinical evaluation of high-performance affinity chromatography for the separation of bone and liver alkaline phosphatase isoenzymes. Clin Chim Acta 1991;199:43-50.
Affinity electrophoresis of human alkaline phosphatase isoenzymes in agarose gel containing lectin.
Age and sex distribution of alkaline phosphatase isoenzymes by agarose electrophoresis.

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