alkaline hematin method

alkaline hematin method

An obsolete colorimetric technique for estimating the blood haemoglobin concentration based on the formation of hematin from haemoglobin, using 0.1 mol NaOH.
References in periodicals archive ?
2% of women with uterine fibroids achieving clinical response compared to placebo, as measured by the alkaline hematin method.
Patients were included if they were premenopausal, aged 18-50 years old, had prolonged bleeding in at least 4 of the last 6 menstrual periods, had menstrual blood loss of at least 80 mL by cycle by the alkaline hematin method, and had at least one discrete leiomyoma without a uterine size greater than 20 weeks.
The primary efficacy outcome of the study is a clinically-meaningful reduction in menstrual blood loss based upon the alkaline hematin method, a standardized centrally-assessed quantitative measurement of menstrual blood loss.
The double-blind, placebo-controlled clinical trial tested premenopausal women between 18 and 50 years old with cyclic (22 to 35 days) abnormal uterine bleeding in >=4 of the last 6 menstrual cycles, menstrual blood loss >=80 mL as measured by the alkaline hematin method over the first 8 days of menses, >=1 discrete uterine fibroid of any size and location observable by transvaginal ultrasound, follicle-stimulating hormone <=20 mIU/mL, and uterine volume <=20 weeks by exam.
The mean change in menstrual blood loss volume, as quantified using the alkaline hematin method, was -353 mL in the E2V/DNG arm vs.
2) In this classic study, Hallberg and colleagues collected menstrual pads and tampons from the women and used the alkaline hematin method to estimate blood loss.
7 percent), as measured by the alkaline hematin method.
The primary endpoint in Phase 3 studies will be the same as in the Phase 2b study: reduction in uterine blood flow as measured by the alkaline hematin method.