Blunk et al (24) concluded that the algogenic
effect of aminosteroidal neuromuscular-blocking drugs could be attributed to a direct activation of C-nociceptors.
They actually used saline as placebo for the intercostals nerve blocks which is not placebo but algogenic
Probably, the pain was milder than that during movement, and normal saline may have local analgesic effect by cooling or diluting intra-articular algogenic
substances, leading to similar pain scores of the two groups with elapsed time.14 Moreover, by preventing the migration and activation of lymphocytes, lidocaine can mitigate local inflammatory response-induced central hyperalgesia and postoperative pain.15
The surgical trauma resulting from the craniotomy releases inflammatory mediators and algogenic
substances that stimulate nociceptors and therefore increase the pain (21).
Thus the facial pain as well as the pain at nerve exit from the stylomastoid foramen would be explained by the involvement nerve trunk nociceptors, while the pain in the retroauricular region and the neck would be generated by algogenic
stimuli from the sheaths of facial nerve delivered to trigeminocervical nuclear complex via nervi nervorum.
Fanciullo, MD, MS (September 2009), nociception is "the strict wiring portion of the neuromatrix experience of pain." Inflammatory pain results from tissue injury followed by an inflammatory reaction that involves the release of "algogenic
" substances that cause sensitization.
Modulation of pain and hyperalgesia from the urinary tract by algogenic
conditions of the reproductive organs in women.
Remote electrodermic response to an algogenic
Falhout, Release of prostaglandins E and F in an algogenic
reaction and its inhibition, Eur J Pharmacol., 51, 17 (1980).
Flahaut, "Release of prostaglandins E and F in an algogenic
reaction and its inhibition," European Journal of Pharmacology, vol.
The overall study suggests that the peripheral analgesic effect of the extract maybe due to inhibition on synthesis or action on algogenic
substances or the inhibition at the central level of the transmission of painful stimuli.
For instance, as the strongest vasodilator substance, CGRP also is endogenous algogenic
substance (Zhang and Zeng 2000), which is widely distributed in trigeminal nerve.