Low-molecular-weight Alg-Na (80-120 cps), ALG-S (swelling type), ALG-NS (nonswelling type), and the model drug VST were obtained from Wako Pure Chemicals (Osaka, Japan).
The solubility of VST was measured in physiological saline containing ALG-S, CS, or chitin.
An additive such as ALG-S was added to the film base solution in order to show that the amount of additive also affects FD preparation.
Conversely, the addition of an anionic polysaccharide, ALG-S, apparently decreased the solubility.
Figure 4 shows the effects of the additive ALG-S on the VST dissolution rate from FDs.
Caption: Figure 4: Effect of ALG-S concentration on VST release from FDs prepared with 1.