Generally, a good response to treatment with alfacalcidol
or calcitriol (10-400 ng/kg/day) is expected in cases with VDDR1A (4,21).
Most clinicians (84%, n=158) prescribe Cholecalciferol, 19 (10.1%) Alfacalcidol
and 11 (5.9%) prescribe Calcitriol as a vitamin D supplement, while 155 (82.4%) prescribe a maintenance dose.
As expected, most studies compared bisphosphonates with Vitamin D analogs (cholecalciferol, alfacalcidol
, and calcitriol) or placebo treatment.
The patient was placed on active vitamin D (alfacalcidol
) and calcium supplements.
The following search terms were used: ("vitamin D" OR "vitamin D2" OR "vitamin D3" OR cholecalciferol OR ergocalciferol OR alphacalcidol OR alfacalcidol
OR calcitriol OR paricalcitol OR doxerocalciferol OR "25 (OH)D") AND (pre-diabet* OR diabet* OR T2DM OR TIIDM or "Type 2 DM" OR "Type II DM" OR insulin OR Homa* OR OGTT OR "impaired fasting glucose" OR IFG OR "fasting plasma glucose" OR FPG OR hba1c OR "beta cell") AND (random* or RCT).
This patient was initially treated with an intravenous calcium infusion and subsequently started on chronic oral calcium supplementation along with alfacalcidol
to maintain a serum calcium level in the low normal range.
(14) with alendronate sodium and alfacalcidol
. Azuma et al.
For the management of CKD-MBD, 76.9% of the patients were on calcium carbonate and 64.3% on alfacalcidol
with a similar distribution of drug usage across the groups.
Calcitriol (1,25-dihydroxycholecalciferol) and alfacalcidol
(1 alpha hydroxycholecalciferol) are not recommended as they may be associated with hypervitaminosis and hypercalcemia; requiring monitoring of serum calcium when initiated on these supplements [30,32,33].
Rasool, "Effects of 1[alpha]-calcidol (alfacalcidol
) on microvascular endothelial function, arterial stiffness, and blood pressure in type II diabetic nephropathy patients," Microcirculation, vol.
Masuda et al., "Clinical trial: Comparison of alendronate and alfacalcidol
in glucocorticoid-associated osteoporosis in patients with ulcerative colitis," Alimentary Pharmacology and Therapeutics, vol.