alendronate


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Related to alendronate: Fosamax, alendronate sodium

alendronate

 [ah-len´dro-nāt]
a calcium-regulating agent used in the form of the sodium salt to inhibit resorption of bone in the treatment of osteitis deformans, osteoporosis, and hypercalcemia related to malignancy; administered orally.

alendronate

(ə-lĕn′drə-nāt′)
n.
A bisphosphonate drug, C4H13NO7P2, that inhibits bone resorption and is used in the form of its sodium salt to treat and prevent osteoporosis in postmenopausal women.

alendronate

A biphosphonate used to treat postmenopausal osteoporosis and Paget’s disease of bone. Alendronate reduces vertebral fractures by 48% and other fractures by 21%, increases bone density by 9% and density of the hip bones by 6% over 3 years of therapy.

Adverse effects
Nausea, stomach pain, constipation, diarrhoea, bloating, headaches, dizziness, swelling of joints (especially of hands and feet).

Mechanism of action
Marked inhibition of bone resorption by inhibiting osteoclastic activity and number of osteoclasts by reducing recruitment, and increasing apoptosis.

alendronate

Fosamax® Endocrinology A biphosphonate used to treat postmenopausal osteoporosis and Paget's disease of bone. See Osteoporosis. Cf Salmon calcitonin.

alendronate

A drug used in the prevention and treatment of post-menopausal OSTEOPOROSIS. A brand name is Fosamax.

Alendronate

A nonhormonal drug used to treat osteoporosis in postmenopausal women.
Mentioned in: Osteoporosis

alendronate

(ă-lendrŏ-nāt)
A bisphosphonate drug used to treat osteoporosis.
[coined term based on parts of the chemical name]
References in periodicals archive ?
Therefore, the present study was designed to investigate the antihyperlipidemic activity of alendronate against Triton X-100-induced hyperlipidemia in rats.
Alendronate was associated with 67% and 45% lower risks of one-year cardiovascular death and heart attack, respectively.
Conclusion: Our study results suggest that alendronate sodium is a valuable treatment agent for osteoporosis in postmenopausal women.
In total, 331 patients were screened at six study sites in China and a total of 240 patients (80 alendronate, 80 QiangGuYin, and 80 placebo) received at least one stage of this study.
By various mechanisms of action, alendronate sodium can enhance bone strength, alleviate and prevent osteoporosis, effectively reduce the risk of fracture in centrum, hip bone and other parts.
In this preliminary study, in which we compared the effect of alendronate therapy versus no bisphosphonates on BMD loss after kidney transplantation, we found significant protection of BMD in the treatment group after 12 and 24 months.
While the potency and composition of the active drug in generic versions of alendronate must be similar to brand alendronate, differences are permitted in their formulation and inactive ingredients (excipients) as long as the proportion of active drug to excipient is constant between the brand and generic forms [10].
(25) These consistent data suggest that alendronate treatment, while increasing the bone mass, decreases the tissue heterogeneity.
Effect of alendronate for reducing fracture by FRAX score and femoral neck bone mineral density: the Fracture Intervention Trial.
The aminobisphosphonate alendronate is primarily used for the treatment of osteoporosis in postmenopausal women and elderly men.