alendronate


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Related to alendronate: Fosamax, alendronate sodium

alendronate

 [ah-len´dro-nāt]
a calcium-regulating agent used in the form of the sodium salt to inhibit resorption of bone in the treatment of osteitis deformans, osteoporosis, and hypercalcemia related to malignancy; administered orally.

alendronate

/alen·dro·nate/ (ah-len´dro-nāt) a bisphosphonate calcium-regulating agent used in the form of the sodium salt to inhibit the resorption of bone in the treatment of osteitis deformans, osteoporosis, and hypercalcemia related to malignancy.

alendronate

(ə-lĕn′drə-nāt′)
n.
A bisphosphonate drug, C4H13NO7P2, that inhibits bone resorption and is used in the form of its sodium salt to treat and prevent osteoporosis in postmenopausal women.

alendronate

a bone-resorption inhibitor.
indications This drug is used to treat osteoporosis in postmenopausal women and Paget's disease.
contraindication Known hypersensitivity to biphosphonates prohibits the use of this drug.
adverse effects Side effects include anemia, hypokalemia, hypomagnesemia, hypophosphatemia, osteonecrosis of the jaw, abdominal pain, anorexia, constipation, nausea, vomiting, bone pain, hypertension, urinary tract infection, and fluid overload.

alendronate

A biphosphonate used to treat postmenopausal osteoporosis and Paget’s disease of bone. Alendronate reduces vertebral fractures by 48% and other fractures by 21%, increases bone density by 9% and density of the hip bones by 6% over 3 years of therapy.

Adverse effects
Nausea, stomach pain, constipation, diarrhoea, bloating, headaches, dizziness, swelling of joints (especially of hands and feet).

Mechanism of action
Marked inhibition of bone resorption by inhibiting osteoclastic activity and number of osteoclasts by reducing recruitment, and increasing apoptosis.

alendronate

Fosamax® Endocrinology A biphosphonate used to treat postmenopausal osteoporosis and Paget's disease of bone. See Osteoporosis. Cf Salmon calcitonin.

alendronate

A drug used in the prevention and treatment of post-menopausal OSTEOPOROSIS. A brand name is Fosamax.

Alendronate

A nonhormonal drug used to treat osteoporosis in postmenopausal women.
Mentioned in: Osteoporosis

alendronate

(ă-lendrŏ-nāt)
A bisphosphonate drug used to treat osteoporosis.
[coined term based on parts of the chemical name]
References in periodicals archive ?
Allen and colleagues did a study with 84 geriatric female beagles, who were treated for 1 year with either risedronate or alendronate at doses equivalent to those used to treat postmenopausal osteoporosis.
Major Finding: At 1 year, the increase in spine bone mineral density was 4% with alendronate, 7% with teriparatide, and 11.
1) The agent's manufacturer also warns that alendronate can cause upper gastrointestinal irritation that can lead to esophagitis, esophageal ulcers, and esophageal erosions with bleeding; in rare cases, esophageal stricture or perforation may occur.
A Danish registry cohort observational study found that fractures in the subtrochanteric and diaphyseal locations were no more frequent in patients receiving alendronate.
was greater than in patients receiving alendronate.
44]Ca values became positive in the alendronate group (P <0.
Results: In the study cohort (N = 10,566), 12-month adherence/persistence rates were alendronate 61%/21%, risedronate 58%/19%, and raloxifene 54%/16%.
Findings suggested that treatment with alendronate was not cost-effective for women whose only fracture risks were age and bone mineral density.
We just don't know and so there are differing opinions about how long alendronate should be taken.
Alendronate is a bisphosphonate that can significantly reduce hip and vertebral fractures when you take 10 mg a day.