aldosterone inhibitors

aldosterone inhibitors

Drugs used to treat refractory oedema resulting from abnormally raised aldosterone levels and to help in the diabnosis and management of CUSHING'S SYNDROME. An example is metyrapone (Metopirone).
References in periodicals archive ?
Chantemele, "Reviving the use of aldosterone inhibitors in treating hypertension in obesity," American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol.
Aldosterone inhibitors (spironolactone) may be suggested to improve pump function and survival in moderate-to-severe HF.
While aldosterone inhibitors are used to treat refractory hypertension, they typically are not used in blacks, possibly because they haven't been well studied in that population, Harshfield said.
In cases where simultaneous treatment with aldosterone inhibitors is reported or known, ultrafiltration of the sample can only partly remove the inhibition and does not lead to a correct result.
Another clinically important finding of this study is the negative interference from compounds other than aldosterone inhibitors. Despite the fact that most immunoassays routinely used to measure digoxin have reasonably low cross-reactivities with the known physiologic hormones (<1%) (2), positive interference has been reported with therapeutically given steroids such as hydrocortisone (33), prednisolone, and other synthetic steroids (34).
* Interference from aldosterone inhibitors is a potential problem in an alarmingly high number of patients, in particular intensive care patients, and is not confined to single, difficult cases (38)
* Low cardiologic doses of aldosterone inhibitors produce limited inhibition only
Assessment of aldosterone inhibitors on digoxin immunoassay performance [Abstract].