aldosterone


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aldosterone

 [al-dos´ter-ōn, al´do-ster-ōn″]
the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II.
aldosterone antagonist a compound that blocks the action of aldosterone; the group includes potassium sparing diuretics such as spironolactone that compete with aldosterone for receptor sites, thus blocking the aldosterone-dependent exchange of sodium and potassium in the distal tubule.

al·dos·ter·one

(al-dos'tĕr-ōn), Avoid the mispronunciation aldoster'one.
A mineralocorticoid hormone produced by the zona glomerulosa of the adrenal cortex; its major action is to facilitate potassium exchange for sodium in the distal renal tubule, causing sodium reabsorption and potassium and hydrogen loss; the principal mineralocorticoid. It exists in equilibrium with the aldehyde form.

aldosterone

(ăl-dŏs′tə-rōn′)
n.
A steroid hormone that is produced by the adrenal cortex and regulates salt balance, blood volume, and blood pressure in the body.

aldosterone

An adrenocortical mineralocorticoid that controls electrolyte and water homeostasis by regulating reabsorption of Na+ and Cl– in exchange for K+ and H+, and which maintains blood pressure and blood volume. Aldosterone secretion is controlled by the RAA system and by concentrations of K+ in the circulation, which if increased evokes secretion of aldosterone. Reduced Na+ evokes renin release, which stimulates aldosterone secretion; aldosterone may be measured when evaluating hypertension.

Increased in
Adrenocortical adenoma or carcinoma, bilateral adrenal hyperplasia, renovascular hypertension, liver disease, congestive heart failure, cirrhosis, nephrotic syndrome, pregnancy (3rd trimester).

Decreased in
Primary hypoaldosteronism, salt-losing syndrome, eclampsia/toxemia of pregnancy, Addison’s disease (chronic adrenal insufficiency).
 
Ref range
• Serum, ≤ 20 mg/dL.
• Urine, ≤ 20mg/24 hours.

aldosterone

Endocrinology An adrenocortical mineralocorticoid hormone that controls the body's electrolyte and water homeostasis by regulating reabsorption of Na+ and Cl– in exchange for K+ and H+ ions, and maintaining BP and blood volume; aldosterone secretion is controlled by the RAA system and by concentrations of K+ in the circulation, which if ↑, evokes secretion of aldosterone; ↓ Na+ evokes renin release, which stimulates aldosterone secretion; aldosterone may be measured when evaluating HTN; aldosterone is ↑ in adrenocortical adenoma or CA, bilateral adrenal hyperplasia, renovascular HTN, liver disease, CHF, cirrhosis, nephrotic syndrome, pregnancy–3rd trimester; it is ↓ in 1º hypoaldosteronism, salt-losing syndrome, toxemia of pregnancy, Addison's disease Ref range Serum, ≤ 20 mg/dL; ≤ 20mg/24hrs, urine. See Hypertension, Pseudoaldosterone, Timed collections.

al·dos·ter·one

(al-dos'tĕr-ōn)
A hormone produced by the cortex of the suprarenal gland; its major action is to facilitate potassium exchange for sodium in the distal renal tubule, causing sodium reabsorption and potassium and hydrogen loss; the principal mineralocorticoid.

aldosterone

One of the STEROID hormones produced by the outer part of the adrenal gland. Aldosterone is concerned with the control of salt and water loss in the urine.

aldosterone

a hormone of the cortex of the ADRENAL GLAND. It is responsible for the relative concentration of sodium and potassium ions in the body. It promotes the reabsorption of sodium ions from the ascending limb of the LOOP OF HENLE in the kidney, with the elimination of potassium ions, and increases the uptake of sodium ions by the alimentary canal. The concentration of sodium ions in the blood thus rises and potassium ions fall, making possible the ionic regulation of body fluids (see SODIUM PUMP).

Aldosterone

A hormone secreted by the adrenal glands that is important for maintaining salt and water balance in the body.

al·dos·ter·one

(al-dos'tĕr-ōn) Avoid the mispronunciation aldoster'one.
Mineralocorticoid hormone produced by the zona glomerulosa of the cortex of the suprarenal gland that facilitates potassium exchange for sodium in the distal renal tubule, causing sodium reabsorption and potassium and hydrogen loss.
References in periodicals archive ?
Among those with a primary aldosteronism phenotype, all patients had variants of aldosterone synthase.
The mechanism underlying tubular unresponsiveness to aldosterone in obstructive uropathy is not definitely known.
There was a negative correlation between plasma sodium and aldosterone levels in seven patients with primary PHA at admission (r=-0.73, p=0.03) (Figure 1).
It is done by catheterization of femoral venous access, sampling blood from both adrenal veins and from the inferior vena cava below the renal veins and measurement of aldosterone and cortisol levels.
Both primary and secondary hyperaldosteronism cause these abnormalities, the former via an appropriate response (renin release) to decreased renal perfusion pressure or decreased sodium concentration in the ultra filtrate, the latter an inappropriate release of aldosterone from the adrenal cortex, often a result of an adrenal adenoma.
The adrenal androgens showed an opposite pattern to that of aldosterone and oxocortisol, with lower concentrations in adrenal CS than in pituitary CS (androstenedione, P = 0.0027; DHEA, P < 0.0001; DHEA-S[O.sub.4], P < 0.0001) and ectopic ACTH-secreting tumors (androstenedione, P = 0.0106; DHEA, P = 0.0273; DHEA-S[O.sub.4], P = 0.0380).
Angiotensin II is essential for the secretion of aldosterone [5] with ACE-I can produce a variable degree of hyporeninemic hypoaldosteronism or type IV renal tubular acidosis [6-10] characterized by metabolic acidosis and hyperkalaemia due to aldosterone deficiency.
Spironolactone (SPR), an antagonist of the aldosterone receptor, is widely used to treat chronic heart failure and edematous conditions.
While these studies [4-9] suggest that there are associations between aldosterone and the components of lipid metabolism in certain patient groups, data from the general population is sparse.
PARIS -- Just when the aldosterone receptor antagonists spironolactone and eplerenone received official recognition in the 2017 U.S.
Loss of hearing is age-related, they say, though the intake of a natural bio-identical hormone called aldosterone can help.
Endocrinological evaluation showed low plasma aldosterone concentration of 40 pg/mL (50~900 pg/mL) and markedly elevated plasma renin activity (PRA) > 200 ng/mL/hr (2.35-370 ng/mL/hr); cortisol level after adrenocorticotropic hormone stimulation was 31.5 ug/dL.