aldose reductase inhibitor


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aldose reductase inhibitor

Any of a family of compounds (e.g., epalrestat, ponalrestat, sorbinil, tolrestat) that block aldose reductase, which catalyses the reduction of glucose to sorbitol; accumulation of polyols through the autosomal recessive pathway is believed to lead to microvascular and neurologic complications of diabetes. Increased intracellular glucose leads to increased sorbitol, which competitively inhibits glomerular and neural synthesis of myo-inositol; the decrease in myo-inositol synthesis depresses phosphoinositide metabolism and reduces Na+K+-ATPase activity. ARIs do not prevent the complications of type-1 diabetes.

aldose reductase inhibitor

Clinical therapeutics Any of a family of compounds–eg, epalrestat, ponalrestat, sorbinil, tolrestat, which block aldose reductase; ↑ intracellular glucose leads to ↑ sorbitol, which competitively inhibits glomerular and neural synthesis of myo-inositol; the ↓ in myo-inositol synthesis depresses phosphoinositide metabolism, and ↓ in Na+K+-ATPase activity; ARIs do not prevent the complications of type 1 DM See Aldose reductase.
References in periodicals archive ?
Cavaliere et al., "A meta-analysis of trials on aldose reductase inhibitors in diabetic peripheral neuropathy," Diabetic Medicine, vol.
La Motta et al., "Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening," Journal of Medicinal Chemistry, vol.
"Oral administration of aldose reductase inhibitors works effectively in experimental animals.
Aldose reductase inhibitors can block the polyol pathway and have been used to deliberate the development of diabetic cardiovascular autonomic neuropathy (DCAN).
Tsubota, "Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235," The British Journal of Ophthalmology, vol.
This aldose reductase inhibitor is in Phase III testing.
Marrazzo et al., "Effect of aldose reductase inhibitor (tolrestat) on urinary albumin excretion rate and glomerular filtration rate in IDDM subjects with nephropathy," Diabetes Care, vol.
Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor. Science 221, 1177-1178.
Several therapeutics, such as aldose reductase inhibitor and [alpha]-lipoic acid, have been developed based on these mechanisms.
Continuous inhibition of excessive polyol pathway flux in peripheral nerves by aldose reductase inhibitor fidarestat leads to improvement of diabetic neuropathy.
LaBarbera, "The isolation and characterization of ^-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis," PLoS One, vol.