Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors
and antioxidant agents for the treatment of diabetic complications.
Cavaliere et al., "A meta-analysis of trials on aldose reductase inhibitors
in diabetic peripheral neuropathy," Diabetic Medicine, vol.
La Motta et al., "Pursuing aldose reductase inhibitors
through in situ cross-docking and similarity-based virtual screening," Journal of Medicinal Chemistry, vol.
"Oral administration of aldose reductase inhibitors
works effectively in experimental animals.
Aldose reductase inhibitors
can block the polyol pathway and have been used to deliberate the development of diabetic cardiovascular autonomic neuropathy (DCAN).
Tsubota, "Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor
, ONO-2235," The British Journal of Ophthalmology, vol.
This aldose reductase inhibitor
is in Phase III testing.
Marrazzo et al., "Effect of aldose reductase inhibitor
(tolrestat) on urinary albumin excretion rate and glomerular filtration rate in IDDM subjects with nephropathy," Diabetes Care, vol.
Retinal capillaries: basement membrane thickening by galactosemia prevented with aldose reductase inhibitor
. Science 221, 1177-1178.
Several therapeutics, such as aldose reductase inhibitor
and [alpha]-lipoic acid, have been developed based on these mechanisms.
Continuous inhibition of excessive polyol pathway flux in peripheral nerves by aldose reductase inhibitor
fidarestat leads to improvement of diabetic neuropathy.
LaBarbera, "The isolation and characterization of ^-glucogallin as a novel aldose reductase inhibitor
from Emblica officinalis," PLoS One, vol.