aldose reductase


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al·dose re·duc·tase

polyol dehydrogenase (NADP+); an oxidoreductase that reversibly converts aldoses to alditols (for example, glucose to sorbitol) with NADPH as hydride donor, an important step in the metabolism of sorbitol and in the formation of diabetes-associated cataracts.
See also: d-sorbitol-6-phosphate dehydrogenase.

aldose reductase

An NADPH-dependent oxidoreductase (EC 1.1.1.21) that catalyses the reduction of various aldehydes and carbonyls (e.g., glucose into sorbitol), which is the first step in the polyol pathway of glucose metabolism. Excess sorbitol in the eye, nerves and kidneys in diabetics leads to retinopathy, neuropathy and nephropathy.

aldose reductase

An enzyme normally present in the eye and elsewhere, which converts excess glucose–as occurs in DM—into sorbitol; excess sorbitol in the eye, nerves, and kidneys can lead to retinopathy, neuropathy, and nephropathy. See Aldose reductase inhibitors.

aldose reductase

An enzyme that makes up part of the metabolic pathway that converts glucose to fructose and sorbitol. Fructose and sorbitol may damage nerves, the retina, and the lens of the eye when they accumulate excessively, e.g., in poorly controlled diabetes mellitus.
References in periodicals archive ?
We investigated the mechanisms whereby melatonin can ameliorate cataract formation in diabetic rats via polyol pathway enzyme inhibition such as aldose reductase and sorbitol dehydrogenase as well as antioxidant status improvement.
The selection of markers was made because hyperoside and quercitrin, members of the flavonoid family, have shown considerable inhibitory effects toward rat lens aldose reductase in a previous report (Lee at al.
Central role for aldose reductase pathway in myocardial ischemic injury," FASEB Journal, vol.
Inhibition of aldose reductase by tannoid principles of Emblica officinalis: implications for the prevention of sugar cataract.
Large format, two-dimensional polyacrylamide gel electrophoresis of ovine periimplantation uterine luminal fluid proteins: Identification of aldose reductase, Cytoplasmic Actin, and Transferrin as conceptus-synthesized proteins.
Using cell culture and laboratory mouse experiments, the researchers showed that the enzyme, aldose reductase, is essential to a process known as goblet cell metaplasia that is seen in both asthma and COPD.
Perhaps the absence of a correlation reflects differing enzyme activities, such as those of aldose reductase, galactokinase, and/or galactose dehydrogenase.
Ranirestat blocks an enzyme called aldose reductase, which interacts with excess blood glucose and converts it to sorbitol.
The company has confirmed that chalcones have insulin-like activity and aldose reductase inhibitory activity so that they help prevent and cure diabetes.
The up-regulated proteins were mostly heat-shock proteins (HSPs) and anti-oxidative stress proteins, including HSP70, aldose reductase, heme oxygenase-1, HSP27, ferritin light chain, and alphaB-crystallin.
Those treatments may include aldose reductase inhibitors, certain nutritional supplements, and antioxidant therapies.
However, there are some specific therapies that are being tested, and once they become available it would be important to be able to use screening to identify which individuals would be able to benefit," she told this newspaper, including aldose reductase inhibitors, certain nutritional supplements, and antioxidant therapies.