The saponin rich fraction D of the butanol extract of Balanites aegyptiaca fruits was found to possess significant aldose
reductase inhibitory activity.
Excess glucose is metabolized by the enzyme aldose
reductase to the polyol sorbitol, which is then metabolized by sorbitol dehydrogenase to fructose.
reductase inhibitors from the leaves of Myrda dubia (H.
However, mice fed a dose of aldose
reductase inhibitor before inhaling ragweed extract showed dramatically reduced levels of these components of the asthmatic response.
The discovery that aldose
reductase regulates mucus production and goblet cell metaplasia makes inhibition of this enzyme an attractive therapeutic option to reduce mucus-related airway obstructive diseases - and for the first time gives us a real chance to alter the course of the underlying disease in asthma and COPD," said UTMB Health biochemistry and molecular biology professor Satish Srivastava, senior author of the paper.
The body also makes fructose by modifying glucose in a process involving an enzyme called aldose
Awad bin Abdul Kader Aldose
, vice-president of the commission on appraisal and real estate auctions, said that the real estate market in the country, which has seen a quantum leap since its inception in 1970, is expected to grow over the next few years.
reductase inhibitors for the treatment of diabetic polyneuropathy.
Autoimmunity in membranous nephropathy targets aldose
reductase and SOD2.
Endoneurial microvessels in human diabetic neuropathy: Endothelial cell dysfunction and lack of effect of aldose
2,5-diketo-D-gluconate reductase from Corynebacterium, aldose
reductase from Hordeum vulgare, and UDP-galactose-4'-epimerase from Trypanosoma brucei were cloned via PCR into a sequencing vector, and subsequently sub-cloned into a glutathione S-transferase expression vector.
Activation of aldose
reductase in rat lens and metal-ion chelation by aldose
reductase inhibitors and lipoic acid.