reductase activity and sorbitol levels in diabetic retinopathy.
reductase and complications of diabetes," Annals of Internal Medicine, vol.
Kinostat' - topical aldose
reductase inhibitor, showed promising in initial clinical trials, but not licensed for use.
Interestingly, resveratrol reduces oxidative stress in diabetes through both deacetylation and inhibition of aldose
reductase [43, 49].
Excessive oxidative stress elevates aldose
reductase activity and stimulates the hexosamine biosynthetic pathway, as well as increasing formation of advanced glycation end-products .
hexaphylla leaves' (SHL) constituents on rat lens aldose
reductase (RLAR) and AGEs.
Identification of phenolic compounds isolated from pigmented rices and their aldose
reductase inhibitory activities.
For example, prostaglandin G/H synthase 2 (T18) has the largest number of drug interactions while aldose
reductase (T47) has only one drug interaction.
reductase (AR) is the first and rate-limiting enzyme in polyol pathway, which catalyzes the reduction of glucose to sorbitol and then sorbitol can be converted to fructose by sorbitol dehydrogenase (SDH).
Chalk C, Benstead TJ, Moore F, 2007, Aldose
reductase inhibitors for the treatment of diabetic polyneuropathy.
The Xerophyta viscose aldose
reductase (ALDRXV4) confers enhanced drought and salinity tolerance to transgenic tobacco plants by scavenging methylglyoxal and reducing the membrane damage.
It is a novel extended release formulation of diepalrestat, a cocrystal of epalrestat, a reversible aldose
reductase inhibitor which blocks the breakdown of excess blood glucose into sorbitol, preventing long-term nerve and tissue damage.