aldolase


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al·dol·ase

(al'dō-lās),
1. Generic term for aldehyde-lyase.
2. Name sometimes applied to fructose-1,6-bisphosphate aldolase.

aldolase

(ăl′də-lās′)
n.
Any of a class of enzymes that reversibly catalyze the cleavage of carbon-carbon bonds, especially the cleavage of sugars into three-carbon fragments during glycolysis.

aldolase

Clinical chemistry A serum enzyme that cleaves fructose 1,6-diphosphate to dihydroxyacetone phosphate and glyceraldehyde-3-phosphate in the muscles to produce energy; aldolase is distributed in all tissues and ↑ in skeletal muscle disease or injury, metastatic CA, CML, megaloblastic anemia, hemolytic anemia, or infarction; it is measured in suspected myopathies, as the intensity of ↑ reflects the severity of disease; aldolase may also be ↑ early in Pts who later develop muscular dystrophy and can also be used to monitor steroid therapy in inflammatory myopathies Ref range 3.1-7.5 U/L; aldolase is ↑ in Duchenne's muscular dystrophy, dermatomyositis, polymyositis, trichinosis

Aldolase

An enzyme, found primarily in the muscle, that helps convert sugar into energy.
Mentioned in: Aldolase Test
References in periodicals archive ?
Uematsu K, Suzuki N, Iwamae T, Inui M, Yukawa H (2012) Increased fructose 1,6-bisphosphate aldolase in plastids enhances growth and photosynthesis of tobacco plants.
Hsu, "Aberrant expression of the glycolytic enzymes aldolase B and type II hexokinase in hepatocellular carcinoma are predictive markers for advanced stage, early recurrence and poor prognosis," Oncology Reports, vol.
Together with the other symptoms of heliotrope rash, elevated aldolase level, elevated C-reactive protein concentration, and positive titers for anti-ARS antibodies, the inclusion of arthralgia fulfilled the diagnostic criteria for DM as stipulated by Japan's Ministry of Health, Labour and Welfare based on Tanimoto et al.
However, before discharge on day 6, thick blood film examination was still positive (192/[micro]L), but by day 11, his repeat blood film examination and his aldolase rapid diagnostic test results were negative.
Exames de calcio, fosforo, magnesio, potassio, sodio, aldolase, ALT, creatinina e ureia encontraram-se dentro dos valores de referencia.
Among the 22 proteins, 11 were identified (Table 1); these were Ulip2 protein, tubulin beta chain 15, a actin, aldolase, M2 pyruvate kinase, panthenol-cytochrome C reductase core protein I, hydrolase at the end of ubiquitin carboxy, albumin, interleukin 1 receptor accessory protein, hemoglobin a chain, kappa-B motif-binding phosphoprotein, and calcium-binding protein.
TABLE 1 Lab test Results Hepatitis A IgM Negative Hepatitis A IgG Negative Hepatitis B surface antigen Negative Hepatitis B core antibody IgM Negative Hepatitis C IgM Negative Hepatitis C IgG Negative HSV PCR Type 1 Negative HSV PCR Type 2 Negative HIV Ab 1 and 2 Reactive HIV-1 discriminatory assay Positive HIV-2 discriminatory assay Negative HIV-1 viral load 115,000 copies/mL HIV-2 viral load Negative CD4 cell count 598 [mm.sup.3] ANA Negative Antimitochondrial antibody Negative Anti-smooth muscle antibody Negative GGT level Negative Creatinine kinase Negative Aldolase Negative Serum RPR titer 1:64TU Treponema pallidum particle Reactive agglutination assay (TPPA) IvCCIV 11 V w Chlamydia DNA probe Nondetected N.
In such instance, glycerol would need to be phosphorylated (by glycerol kinase, which we could not detect in symbiotic or bleached anemones) and oxidized back to DHAP, to be condensed into 1,6 bisphosphate (by the reversible action of aldolase), needing 2 molecules of ATP and being therefore an energy-consuming pathway.
The primary objective was to create a system that would have similar sensitivity as a standard 96-well ELISA in detecting Plasmodium aldolase while using less reagent volume and cheaper equipment and without the need for AC power.
Labs supportive ofmyositis included elevated creatinine kinase (6201U/L), aldolase (42U/L), LDH (747 U/L), and myoglobin (2843 mcg/L).
Tests measuring creatinine kinase, aldolase, toxicology, and thyroid function were within normal ranges.