aldehyde reductase

al·co·hol de·hy·dro·gen·ase (NADP+)

(al'kŏ-hol dē-hī-droj'e-nās),
An oxidoreductase that reversibly converts alcohols to aldehydes (or ketones) with NADP+ as hydride acceptor.
Synonym(s): aldehyde reductase
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 4q21-23 that encodes class-I alcohol dehydrogenase, alpha subunit, a member of the alcohol dehydrogenase family, which metabolise various substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids and lipid peroxidation products. The encoded protein plays a major role in ethanol catabolism and is highly expressed in adults livers.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Aldehyde dehydrogenases mediate the oxidative pathway of carbonyls, forming carbonic acids [71, 72]; glutathione-S-transferases (GST) catalyze the conjugation of carbonyls with glutathione [73-75]; and aldehyde reductase and aldo-keto reductases (AKRs) are responsible for the reduction of carbonyls to alcohols with NAD(P)H as a coenzyme [75-77].
Carbonyl compounds Carbonyl clearance Acrolein (C[H.sub.2]=CHCHO) Glyoxal (OHCCHO) Methylglyoxal (C[H.sub.3]COCHO) (1) Glutathione-S-transferases (GST) catalyze carbonyl- glutathione conjugation Crotonaldehyde (C[H.sub.3]CH=CHCHO) (2) Aldehyde reductase and aldo-keto reductases (AKRs) catalyze reduction to alcoholic forms Malondialdehyde (OCHC[H.sub.2]CHO) (3) Aldehyde dehydrogenases catalyze oxidation to carbonic acids 4-Hydroxynonenal (OCHCH=CHCH(-OH) [(C[H.sub.2]).sub.4]C[H.sub.3]) Table 3: Carcinogenic role of carbonyl compounds.
Aldehyde dehydrogenase and aldehyde reductase in isolated bovine brain microvessels.