Anthropometric measurements and laboratory investigations in the two patients Case 1 Case 2 Age at diagnosis (years) 16 20 Bone age (years) 3 15 Weight (kg)/Z-score 26/-7.46 47/-3 Height (cm)/ Z-score 96/-10.45 133.4/-6 ALT (IU/L) (<33) 44 25 AST (IU/L) (<32) 55 56 Triglyceride (mg/dL) (<200) 726 126 Cholesterol (mg/dL) (<200) 266 315 CPK (U/L) 545 478 (20-180) Ferritin (ng/mL) (20-200) 4.32 89 Vitamin B12 (pg/mL) (191-663) 181.7 275 Hemoglobin (g/dL) (12-18) 5.6 12.9 Mean corpuscular volume (fL) 94.4 87.3 (80-100) CPK: creatinine phosphokinase, AST: aspartate transaminase, ALT: alanine transaminase
Parameter Result Age, years 49 BMI, kg/[m.sup.2] 30.6 BP, mmHg 142/90 HbA1c, mmol/mol 41 Lipids, mmol/L Total cholesterol 7.1 LDL 5.3 TG 1.5 Liver function AST, U/L (normal 2-40) 110 ALT, U/L (normal 2-60) 232 Endocrine evaluation UFC, nmol/d (normal 11-138) 172.8 1-mg DST, nmol/L (normal < 49.5) 364.3; 345.0 Late night salivary cortisol, nmol/L (normal < 2.5) 5.2 ACTH, pmol/L (normal 1.1-9.9) <1.1 x 2 DHEA-S, [micro]mol/L (normal 1.1-7.9) 0.54 ACTH, adrenocorticotropic hormone; ALT, alanine transaminase
; AST, aspartate transaminase; BMI, body mass index; BP, blood pressure; DHEA-S, dehydroepiandrosterone sulfate; DST, dexamethasone suppression test; HbA1c, glycated hemoglobin A1c; LDL, low-density lipoprotein; TG, triglyceride; UFC, urinary free cortisol.
There were no statistical differences between the 2 groups with regard to age, sex, comorbidity (including hypertension, diabetes mellitus, chronic renal failure, peripheral arterial disease, atrial fibrillation, and rheumatic heart disease), symptoms (including abdominal pain, nausea, intestinal obstruction, and bloody diarrhea), and laboratory results (including white blood cell count, blood urea nitrogen, creatinine, aspartate transaminase, alanine transaminase
, lactate, D-dimer, and fibrinogen) (all p > 0.05, Table 2).
Fasting blood tests were taken at baseline and at the end of study and assessed for fasting blood glucose (FBG) serum total cholesterol, TGs, LDLC, high-density lipoprotein cholesterol (HDL-C), and liver enzymes including alanine transaminase
(ALT), aspartate transaminase (AST) and creatinine.
Assessment of liver cell injury is done by the estimation of serum aspartate transaminase or AST (formerly glutamic oxaloacetic transaminase or SGOT) and serum alanine transaminase
or ALT (formerly glutamic pyruvic transaminase or SGPT).
Some studies have demonstrated no change in aspartate transaminase (AST) and alanine transaminase
(ALT), but a rise in bilirubin levels.
Once samples were received, analysis for glucose (fasting and 2 h), glycated hemoglobin (HbA1c), creatinine, sodium, potassium, uric acid, aspartate transaminase (AST), alanine transaminase
(ALT), gamma-glutamyl transferase, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, thyroid stimulating hormone (TSH), insulin (fasting and 2 h) and ultrasensitive C-reactive protein, as well as serology for Chagas disease were performed.
Mean liver aspartate aminotransferase at the end of the experiment in groups A, B and C were 97.8819.45, 148.2516.48 and 96.1317.95U/L, while alanine transaminase
levels were 51.5015.38, 96.7510.91 and 49.6312.08 U/L (pless than 0.05 each) On histological examination of group B, the normal hepatic architecture was distorted with loss of classically arranged hepatic cords.
Blood collected at the time of admission showed leukopenia (0.90 x [10.sup.9] cells/L), neutropenia (0.31 x [10.sup.9] cells/L), lymphocytopenia (0.59 x [10.sup.9] cells/L), thrombocytopenia (76 x [10.sup.9] platelets/L), anemia (hemoglobin 8.2 g/dL), and elevated serum concentrations of aspartate transaminase (2,748 IU/L) and alanine transaminase
The prevalence of elevated alanine transaminase
and its possible causes in the general Korean population.
Creasey et al., "The association of alanine transaminase
with aging, frailty, and mortality," Journals of Gerontology--Series A Biological Sciences and Medical Sciences, vol.
During the treatment period, hemoglobin, ferritin, aspartate transaminase, alanine transaminase
, total bilirubin, and direct bilirubin levels were recorded daily.