alanine aminotransferase


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Related to alanine aminotransferase: aspartate aminotransferase

alanine aminotransferase

 [al´ah-nēn ah-me″no-trans´fer-ās]
ALT; alanine transaminase.

al·a·nine a·mi·no·trans·fer·ase (ALT),

(al'ă-nēn a-mē'nō-tranz'fer-ās),
An enzyme transferring amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); one d-alanine transaminase effects the same reaction, but using d-alanine and d-glutamate. Serum concentration is increased in viral hepatitis and myocardial infarction.

alanine aminotransferase

/al·a·nine ami·no·trans·fer·ase/ (ah-me″no-trans´fer-ās) alanine transaminase.

alanine aminotransferase (ALT)

an enzyme normally present in the serum and tissues of the body, especially the tissues of the liver. This enzyme catalyzes the transfer of an amino group from alanine to alpha-ketoglutarate, forming pyruvate and glutamate. The reaction is reversible. The enzyme is released into the serum as a result of tissue injury and increases in persons with acute liver damage. Normal findings are 5 to 35 IU/L. Also called alanine transferase, glutamic pyruvic transferase, serum glutamic pyruvic transaminase (SGPT). Compare aspartate aminotransferase.

alanine aminotransferase

Glutamine pyruvic transaminase, GPT Clinical chemistry An enzyme found primarily in the liver, with lesser amounts in the kidneys, heart and skeletal muscles; low levels of ALT are normal in the circulation; after liver damage, ALT is released into the bloodstream before more obvious clinical findings of liver damage–eg jaundice, occur; ↑ ALT is an early indicator of acute liver damage; ALT is measured as part of a panel of blood chemistry tests Ref ranges ♂ 10-32 U/L; ♀ 9-24 U/L; children 2 times > adults; AA is ↑ in viral hepatitis, drug-induced hepatitis, infectious mononucleosis, chronic hepatitis, intrahepatic cholestasis, cholecystitis, active cirrhosis, acute MI. See Aspartate amino transferase, Gamma-glutamyl transferase.

al·a·nine a·mi·no·trans·fer·ase

(ALT) (al'ă-nēn ă-mē'nō-trans'fĕr-ās)
An enzyme transferring amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction.
Synonym(s): glutamic-pyruvic transaminase, serum glutamic-pyruvic transaminase.

al·a·nine a·mi·no·trans·fer·ase

(ALT) (al'ă-nēn ă-mē'nō-trans'fĕr-ās)
An enzyme transferring amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction.
Synonym(s): glutamic-pyruvic transaminase, serum glutamic-pyruvic transaminase,
alanine transaminase.

alanine aminotransferase

an enzyme that catalyzes the reversible transfer of an amino group in the reaction:
$$\hbox{alanine + 2-oxoglutarate \leftrightharpoonsarrow\,\! pyruvate + glutamate}$$
requiring the coenzyme pyridoxal phosphate. Abbreviated ALT. It is present in high concentrations in hepatocytes of dogs, cats and humans. The serum concentration is elevated, especially when there is acute damage to liver cells, as in viral or toxic hepatitis, and obstructive jaundice. Significant elevation of the serum levels of ALT is a specific indicator of liver damage only in small animals and primates. Called also glutamic-pyruvic transaminase (GPT).
References in periodicals archive ?
Influence of Local Reference Populations on Upper Limits of Normal for Serum Alanine Aminotransferase Levels.
Of the 24 positive subjects, all nine from the terai area had normal alanine aminotransferase, whereas 7 of the 15 subjects of the hilly region had elevated alanine aminotransferase (Table 3), indicating the association of positivity of HBsAg in them with elevated alanine aminotransferase ([chi square]=11.
Since the study area was in resource poor setting, only Alanine aminotransferase (ALT) level was followed up at 3 months and 6 months after initiation of ART.
He had severe thrombocytopenia (4,000 platelets/[micro]L); mild anemia (hemoglobin level 88 g/L); increased levels of aminotransferases (aspartate aminotransferase 282 U/L, alanine aminotransferase 489 U/L), lactate dehydrogenase (1,041 U/L [reference range 105 U/L-333 U/L]), D-dimer (6,311 ng/ mL [reference range 10 ng/mL-250 ng/mL]), C-reactive protein (237.
5 Chloride, mmol/L 101 97-110 Glucose, mg/dL 127 65-110 Alanine aminotransferase, U/L 9 0-35 Aspartate aminotransferase, U/ 20 0-40 Creatinine, mg/dL 0.
Placebo was associated with a significant increase from baseline in body mass index, alanine aminotransferase and aspartate aminotransferase (0.
The blood was allowed to clot and serum was separated for estimation of serum malondialdehyde (MDA) levels on spectrophotometer; and serum alanine aminotransferase (ALT) levels and aspartate aminotransferase (AST) levels on Merck Micorlab 200.
Objective: To investigate the relationship between hepatitis B virus (HBV) genotypes and hepatitis B early antigen (HBeAg) as well as the hepatitis C antibody, alanine aminotransferase (ALT) levels and liver inflammation and damage in chronic patients of hepatitis B.
Quantitative analysis of plasma biochemical parameters total protein, creatinine, glucose, lactate dehydrogenase (LDH), urea, cholesterol, alanine aminotransferase (ALAT), and aspartate aminotransferase (ASAT) was done by using Photolab 1400.
The concentration of plasma urea nitrogen, alanine aminotransferase, aspartate aminotransferase, total cholesterol, low-density lipoprotein, high-density lipoprotein and creatinine was measured with an Automatic Biochemical Analyzer (RA-1000; Bayer Corporation, Tarrytown, NY) using colorimetric methods and the instructions from the manufacturer's reagent kit (Zhongsheng Biochemical Company, Beijing, China).
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were established using routine clinical chemistry testing.
Among the patients with abnormal alanine aminotransferase levels at baseline, more of those treated with entecavir achieved normal levels at 48 weeks, compared with those treated with adefovir (63% vs.