[30,31] Moreover, chronic beta-2 agonists usage had been linked to heightened airway responsiveness
to allergen exposure and produced tolerance to relieving effect from methacholine and allergen-induced bronchoconstriction.
Different potentials of gamma delta T cell subsets in regulating airway responsiveness
: V gamma 1+ cells, but not V gamma 4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation.
Relation between airway responsiveness
and serum IgE in children with asthma and in apparently normal children.
A high concentration of 8-iso is thought to increase airway responsiveness
, and can increase the production of mucus and cause contraction of the airway muscles, making it difficult to breathe.
'Asthma is linked to hay fever and eczema through intermediate phenotypes like clinical measures of lung function, physiological measures of airway responsiveness
, and the biomarker exhaled nitric oxide, all of which are influenced by hereditary factors," the authors said.
An early-stage asthma attack is characterized by an airway mucosal edema, airway infiltration of inflammatory cells (e.g., eosinophils), inflammatory cytokines produced by recruited cells, increased airway responsiveness
, and limited airflow reversibility.
Airway myocytes from CD38 knockout (CD38KO) mice exhibit attenuated intracellular [Ca.sup.2+] ([[[Ca.sup.2+]].sub.i]) responses to agonists  and methacholine-induced airway responsiveness
in the CD38KO mice is lower than in wild-type (WT) mice.
On dedicated sets of mice, airway responsiveness
to methacholine challenge was studied, as described previously .
Acute [O.sub.3] exposure also increases pulmonary mechanics in obese but not lean mice and causes greater increases in airway responsiveness
in obese than lean mice (Williams et al.
In recent years, significant evidence from birth cohort studies has been indicating that reduced neonatal lung function and increased airway responsiveness
are associated with respiratory symptoms and asthma later in life.[sup],,,, However, due to the difficulty in performing a routine lung function test, relatively little is known about the lung function in infants with wheezing after respiratory infection.
To evaluate the effect of AS-IV on OVA-induced AHR, the airway responsiveness
to aerosolized PBS or methacholine was assessed within 24 h after the final challenge.
to nonspecific stimuli, such as methacholine, is an important tool for diagnosis of asthma and monitoring the responses to asthma therapies in children and adults [1,2].