airway remodeling

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airway remodeling

Pathological changes in bronchi and bronchioles that occur in chronic asthma. These include increases in airway collagen, airway smooth muscle, and goblet cells.pickup.

See also: remodeling

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Many of the fibroblast responses that occur in airway remodeling are comparable to the interaction between cancer cells and connective tissue cells called stromal fibroblasts.

The invasion of fibroblasts into the airway in asthmatic patients is one of several key features of airway remodeling," Dr.

Protein linked to allergic response causes airway changes in asthmatics

Accordingly, the present study suggests a potential involvement of PAF in airway remodeling due to its direct stimulation of ASMC proliferation, which broadens the role of PAF in the pathogenesis of COPD and provides a new theoretical basis for the special treatment of COPD targeting against PAF.

Thus our findings not only suggest the promosing action of NAC on the alleviation of airway remodeling in COPD but also provide a potentially theoretical basis for clinical administration of NAC at higher doses.

Effect of platelet-activating factor on cell proliferation & NF-[kappa]B activation in airway smooth muscle cells in rats

1], suggesting once more that the daily ICS does not have an effect on airway remodeling (N.

97), no change in hospitalizations or lung function, and no benefit on airway remodeling (N.

Are daily inhaled steroids appropriate for mild persistent asthma?

Additional presented data provide insight to IL-9's role in allergen-induced airway remodeling, a process involving structural changes that occur in conjunction with, or as a result of, chronic airway inflammation such as that seen in patients with asthma.

MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations

For example, one hypothesis is that recurrent inflammatory or allergic challenges to the airway leads to airway remodeling, a key feature in the development of irreversible airways obstruction in asthma and COPD.

The U.S. Environmental Protection Agency particulate matter health effects research centers program: a midcourse report of status, progress, and plans. (Research Review)

1992), and in both of these groups, airway remodeling of this type appears to be associated with chronic airflow obstruction.

Chronic exposure to high levels of particulate air pollution and small airway remodeling. (Research)

Asthma is a chronic disease characterized by acute airway constriction, chronic inflammation, and airway remodeling.

Researchers Present New Findings on the Role of Inflammation in Allergic Disease at 2005 AAAAI Annual Meeting

Regulation of Extracellular Matrix Components by Beta-Agonist Enantiomers: A Possible Role for Airway Remodeling.

13 Abstracts on Isomers of Beta-Agonists to Be Presented at ATS Conference

In pre-clinical studies, CpG-based products have been shown to be long-lasting and have demonstrated the ability to help prevent airway remodeling associated with chronic symptoms, offering the potential to alter the effects of allergic disease.