airway remodeling


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airway remodeling

Pathological changes in bronchi and bronchioles that occur in chronic asthma. These include increases in airway collagen, airway smooth muscle, and goblet cells.pickup.
See also: remodeling
References in periodicals archive ?
Recently, Sze and colleagues (34) have found not only that analysis of the microbiome can be used to discriminate between control and severe COPD lung tissue, but they also demonstrated that a decline in microbial diversity correlated with emphysematous lung destruction, airway remodeling, and CD4 T-cell lymphocyte accumulation within the lung.
Airway remodeling in asthma and irreversible airow limitation-ECM deposition in airway and possible therapy for remodeling.
In our opinion the close correlation between inflammation and airway remodeling has been confirmed in some literatures.
We don't have a cure, and we certainly don't have good drugs to target airway remodeling," Dr.
Those molecules control collagen deposition, and a correct ratio of them is needed to prevent airway remodeling.
Our study also suggested the promising action of 20mM NAC on the alleviation of airway remodeling due to direct inhibition of ASMC proliferation.
It is associated with an extensive array of symptoms that include mucus hyper-secretion, airway hyper-responsiveness (AHR), and airway remodeling (1).
Researchers tested the efficacy of the MSCs on three key components of asthma in a preclinical model of chronic allergic airways disease: inflammation; airway remodeling (structural changes that occur in lungs as a result of prolonged inflammation); and airway hyper-responsiveness (the clinical symptom of asthma).
sup][11] Furthermore, it has been shown that neutrophils play a vital role in the exacerbation of asthma by inducing mucus hypersecretion and airway remodeling, which results in acute reversible and progressive irreversible airway obstruction, respectively.
Small airway remodeling in idiopathic interstitial pneumonias: a pathological study.
sup][9] Airway remodeling is a classic feature, which is characterized by changes in the airway tissue architecture, including increased extracellular matrix deposition and airway smooth muscle accumulation.
In recent years, the contributions of inflammatory mechanisms to airway remodeling have been investigated.

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