Soluble ADAM33 initiates
airway remodeling to promote susceptibility for allergic asthma in early life.
These results will contribute to a better understanding of the
airway remodeling occurring in patients with COPD who are exposed to PM2.5 and the development of new therapeutic approaches.
Mattoli, "A mouse model for evaluating the contribution of fibrocytes and myofibroblasts to
airway remodeling in allergic asthma," Methods in Molecular Biology, vol.
Anthocyanidins, flavonols (quercetin and kaempferol), flavones (apigenin and luteolin), and isoflavones (genistein) have been reported to ameliorate
airway remodeling and the inflammatory response in mice [26, 27].
Evaluation of Lung Emphysema and
Airway Remodeling. After blood and BAL collection, the lungs were carefully removed, perfused and fixed using 4% formalin for 24 hours at a positive pressure (20 cm [H.sub.2]O), and submitted to histological routine.
MMP-9 is involved in the pathogenesis of COPD
airway remodeling [16] and is inhibited by TIMP-1 in a 1 : 1 proportion.
Holgate, "
Airway remodeling in asthma: new insights," Journal of Allergy and Clinical Immunology, vol.
The practicing pathologist can certainly comment on the extent and severity of the above-described
airway remodeling. As a caution, however, although goblet cell metaplasia is a feature of asthma, its presence should not cause the pathologist to suggest that airway hyperresponsiveness may be present in COPD; indeed, there is sufficient overlap between the airway pathology of asthma and that of COPD that a definitive separation based solely on evaluation of the conducting airways is quite difficult.
Keywords: Anti-inflammatory, Chronic asthma, Mouse, Interleukin-5, Methyl palmitate,
Airway remodeling. (JPMA 65: 632; 2015)
Airway remodeling in COPD is a direct result of the inflammatory
In chronic aiiways inflammation pathologies like asthma, tissue damage and structural changes are labelled as airway remodelling [69, 70], These structural changes range from epithelial goblet cell hyperplasia, mucous gland hyperplasia-metaplasia [2] reticular basement membrane thickening and increased vascularity of mucosa with thickening of smooth muscle layer [30, 51, 69], RAO
airway remodeling ranges from epithelial goblet cell hyperplasia, mucous gland hyperplasia-metaplasia, reticular basement membrane thickening and increased vascularity of mucosa with thickening of smooth muscle layer [38, 69].
Treatment with fluticasone propionate (FP) and salmeterol (SM) improved allergen-induced
airway remodeling [12] and was able to control peripheral blood T-cell activation in asthmatic patients more efficiently [12].
