Conclusion: Salbutamol significantly inhibited the contractile response of insulin, while montelukast did not produce statistically significant effect on insulin induced airway hyper-reactivity. So it is suggested that pretreatment of inhaled insulin with salbutamol may be beneficial in inhibiting the broncho-constriction induced by insulin.
Prophylactic use of montelukast decreases the symptoms of airway hyper-reactivity induced by variety of allergens and chemicals9.
Salbutamol shifted the concentration response curve of insulin to the right and downwards.Conclusions: Salbutamol significantly reduced the insulin mediated airway hyper-reactivity in guinea pigs suggesting that pre-treatment of inhaled insulin with salbutamol may have clinical implication in the amelioration of its potential respiratory adverse effects such as bronchoconstriction.Keywords: Histamine Inhaled insulin Oscillograph Tracheal muscle.
The objective of the study was to determine the magnitude of insulin-induced airway hyper-reactivity and its treatment with salbutamol.
Insulin concentration response curve in the presence of salbutamol was shifted to the right and downwards indicating a profound inhibitory effect of salbutamol on airway hyper-reactivity induced by insulin.
When untreated mice inhaled ragweed extract, their lungs suffered an influx of eosinophils (inflammation-inducing white blood cells), a jump in inflammatory signaling molecules, a buildup of mucin (a protein component of mucus) and an increase in airway hyper-reactivity
(the tendency of air passages to suddenly constrict under stress).
Magnesium intake is inversely related to the risk of airway hyper-reactivity
Asthma is a chronic inflammatory disease with reversible airway obstruction and nonspecific airway hyper-reactivity. The local release of sensory neuropeptides from capsaicin-sensitive primary afferents causes motor neuron pathophysiology and airway inflammation and hyper-reactivity.
Asthma is a chronic inflammatory disease characterized by reversible airway obstruction, nonspecific airway hyper-reactivity, extensive neurogenic inflammatory responses involving local activation of in the inflammatory regions of neuropeptides which results in further neuron and inflammatory actions.
airway hyper-reactivity (asthma), bronchiectasis and bronchiolitis obliterans or reduced (restrictive lung function) with pathologies that involve the lung parenchyma (ILD), the pleura or the thoracic cage.
Airways: large airways for airway hyper-reactivity or scarring from bronchiectasis, smaller airways for air-trapping and bronchiolitis obliterans
Cough may persist for many weeks after an acute viral upper respiratory tract infection, and a positive challenge test in this circumstance may be diagnostically misleading because transient airway hyper-reactivity