Mei, "LRP4 serves as a coreceptor of agrin
," Neuron, vol.
van den Born et al., "Agrin
is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain," The American Journal of Pathology, vol.
Currently, gene defects that influence the development and maintenance of NMJ are assigned to a separate group of the CMS and rank second in the disease causes following defects of the acetylcholine receptors (AChRs).[sup] These genes include RAPSN , DOK7 , LRP4 , MUSK , and AGRN .[sup], Agrin
, encoded by AGRN , is a cell-specific heparan sulfate proteoglycan generated by alternative splicing.
The researchers identified a protein called agrin
, which is expressed during embryonic development but stops shortly after birth.
Other non-HLA antigens that have been shown to play a role in kidney allograft rejection include perlecan, Col IV, Col VI, and the glomerular basement membrane protein, agrin
Comparing with the normal group, the signal densities of cytokines were upregulated in the MNNG-induced gastric cancer groups, including Activin A, Agrin
, IL-1a (both P < 0.01), ICAM-1 (P < 0.001), and TIMP-1 (P < 0.05).
Reportedly, neurotrypsin can produce C-terminal agrin
fragment that plays crucial roles in the initiation and maintenance of neuromuscular junctions and is a biomarker of muscle wasting in congestive heart failure patients (31).
Rogers, "Association of factor H of the alternative pathway of complement with agrin
and complement receptor 3 in the Alzheimer's disease brain," Journal of Neuroimmunology, vol.
We also examined acetylcholinesterase (AchE) and Agrin
expression in the neuromuscular junction (NMJ) via immunohistochemistry.
iNaturalist.org began as a master's degree project of Nate Agrin
, Jessica Kline, and Ken-ichi Ueda at UC Berkeley's School of Information in 2008.
This analysis revealed three top-ranking pathways, which are listed in their respective order: complement and coagulation cascades (14 downregulated genes in the H group), systemic lupus erythematosus (14/16 downregulated genes in the H group) and ECM -receptor interactions (7 downregulated genes, including collagen, type IV, alpha 6 (COL4A6), tenascin C (TNC), secreted phosphoprotein 1 (SPP1), collagen, type I, alpha 2 (COL1A2), COL1A1, CD44 molecule (CD44), and ribosomal protein L26 (RPL26), and 5 upregulated genes, including integrin, beta 6 (ITGB6), syndecan 4 (SDC4), agrin
(AGRN), thrombospondin 4 (THBS4), BT.3034.
Mars et al., "Neural agrin
controls maturation of the excitation-contraction coupling mechanism in human myotubes developing in vitro," American Journal of Physiology--Cell Physiology, vol.