agrin


Also found in: Dictionary, Wikipedia.

Agrin

A 150-kD extracellular matrix proteoglycan encoded by AGRN on chromosome 1p36.33, which plays a central role in the embryonic development of the neuromuscular junction, first identified in the synapse-rich electric organ of Torpedo californica which induces myotubular synaptic specialisation.

agrin

A protein released by motor neurons that brings about the close aggregation of acetylcholine receptors on muscle cells.
References in periodicals archive ?
Mei, "LRP4 serves as a coreceptor of agrin," Neuron, vol.
van den Born et al., "Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain," The American Journal of Pathology, vol.
Currently, gene defects that influence the development and maintenance of NMJ are assigned to a separate group of the CMS and rank second in the disease causes following defects of the acetylcholine receptors (AChRs).[sup][2] These genes include RAPSN , DOK7 , LRP4 , MUSK , and AGRN .[sup][3],[4] Agrin, encoded by AGRN , is a cell-specific heparan sulfate proteoglycan generated by alternative splicing.
The researchers identified a protein called agrin, which is expressed during embryonic development but stops shortly after birth.
Other non-HLA antigens that have been shown to play a role in kidney allograft rejection include perlecan, Col IV, Col VI, and the glomerular basement membrane protein, agrin [93, 94].
Comparing with the normal group, the signal densities of cytokines were upregulated in the MNNG-induced gastric cancer groups, including Activin A, Agrin, IL-1a (both P < 0.01), ICAM-1 (P < 0.001), and TIMP-1 (P < 0.05).
Reportedly, neurotrypsin can produce C-terminal agrin fragment that plays crucial roles in the initiation and maintenance of neuromuscular junctions and is a biomarker of muscle wasting in congestive heart failure patients (31).
Rogers, "Association of factor H of the alternative pathway of complement with agrin and complement receptor 3 in the Alzheimer's disease brain," Journal of Neuroimmunology, vol.
iNaturalist.org began as a master's degree project of Nate Agrin, Jessica Kline, and Ken-ichi Ueda at UC Berkeley's School of Information in 2008.
This analysis revealed three top-ranking pathways, which are listed in their respective order: complement and coagulation cascades (14 downregulated genes in the H group), systemic lupus erythematosus (14/16 downregulated genes in the H group) and ECM -receptor interactions (7 downregulated genes, including collagen, type IV, alpha 6 (COL4A6), tenascin C (TNC), secreted phosphoprotein 1 (SPP1), collagen, type I, alpha 2 (COL1A2), COL1A1, CD44 molecule (CD44), and ribosomal protein L26 (RPL26), and 5 upregulated genes, including integrin, beta 6 (ITGB6), syndecan 4 (SDC4), agrin (AGRN), thrombospondin 4 (THBS4), BT.3034.
Mars et al., "Neural agrin controls maturation of the excitation-contraction coupling mechanism in human myotubes developing in vitro," American Journal of Physiology--Cell Physiology, vol.