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4) Centrally Acting Drugs 4a) Compounds Predominantly Modulating Local Availability of Dopamine, Norepinephrine and Serotonin in the Brain 4b) MC4R (Melanocortin 4 Receptor) Agonists and MCH-R1 (Melanin-Concentrating Hormone Receptor 1) Antagonists 4c) H3 Receptor Antagonists 4d) Neuropeptide Y (NPY) Receptor Antagonists & Agouti-Related Protein (AgRP) Inhibitors
HMS is composed of two different populations of neurons, one set that expresses neuropeptides Y (NPY) and agouti-related protein (AgRP) and a second set that expresses proopiomelanocortin (POMC), a precursor containing a-melanocyte-stimulating hormone (Richards et al.
The newly identified protein, agouti-related protein (AGRP), may be an ideal target for such an approach, he said.