Agouti-related protein | definition of agouti-related protein by Medical dictionary
Also found in: Acronyms
agouti-related protein (AGRP),
a protein that plays a role in maintaining body weight by inducing food intake; its nucleotide sequence or gene resides on chromosome 16 and has polymorphisms that potentially seem related to anorexia.
Agouti-Related Peptide A peptide produced in the arcuate nucleus in the hypothalamus, which increases appetite (an action countered by leptin), but reduces the rate of metabolism and energy expenditure. It is increased in obese subjects.
References in periodicals archive
Two ethnic-specific polymorphisms in the human Agouti-related protein
gene are associated with macronutrient intake.
Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein
(AGRP) has a central inhibitory action on the hypothalamic-pituitarythyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis.
4) Centrally Acting Drugs 4a) Compounds Predominantly Modulating Local Availability of Dopamine, Norepinephrine and Serotonin in the Brain 4b) MC4R (Melanocortin 4 Receptor) Agonists and MCH-R1 (Melanin-Concentrating Hormone Receptor 1) Antagonists 4c) H3 Receptor Antagonists 4d) Neuropeptide Y (NPY) Receptor Antagonists & Agouti-Related Protein
The melanocortin 4 receptor protein regulates the food intake process and body weight in cooperation with leptin and agouti-related protein
(AGRP), thus playing an important role in the maintenance of proper body weight (Dhillo et al.