agouti-related protein

Also found in: Acronyms.

agouti-related protein (AGRP),

a protein that plays a role in maintaining body weight by inducing food intake; its nucleotide sequence or gene resides on chromosome 16 and has polymorphisms that potentially seem related to anorexia.

Agouti-Related Peptide

A peptide produced in the arcuate nucleus in the hypothalamus, which increases appetite (an action countered by leptin), but reduces the rate of metabolism and energy expenditure. It is increased in obese subjects.
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References in periodicals archive ?
Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children.
Plasma levels of agouti-related protein are increased in obese men.
Plasma agouti-related protein levels in women with anorexia nervosa.
Agouti-related protein in patients with acute and weight-restored anorexia nervosa.
Association between an agouti-related protein gene polymorphism and anorexia nervosa.
Deletion of agouti-related protein blunts ethanol self-administration and binge-like drinking in mice.
Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.
Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitarythyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis.
The melanocortin 4 receptor protein regulates the food intake process and body weight in cooperation with leptin and agouti-related protein (AGRP), thus playing an important role in the maintenance of proper body weight (Dhillo et al., 2002; Switonski, 2013).
HMS is composed of two different populations of neurons, one set that expresses neuropeptides Y (NPY) and agouti-related protein (AgRP) and a second set that expresses proopiomelanocortin (POMC), a precursor containing a-melanocyte-stimulating hormone (Richards et al., 2010).