agouti-related protein

Also found in: Acronyms.

agouti-related protein (AGRP),

a protein that plays a role in maintaining body weight by inducing food intake; its nucleotide sequence or gene resides on chromosome 16 and has polymorphisms that potentially seem related to anorexia.

Agouti-Related Peptide

A peptide produced in the arcuate nucleus in the hypothalamus, which increases appetite (an action countered by leptin), but reduces the rate of metabolism and energy expenditure. It is increased in obese subjects.
Mentioned in ?
References in periodicals archive ?
Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake.
Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist.
Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitarythyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis.
The melanocortin 4 receptor protein regulates the food intake process and body weight in cooperation with leptin and agouti-related protein (AGRP), thus playing an important role in the maintenance of proper body weight (Dhillo et al.